Acta Metallurgica Sinica

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Aspirin and heart health in females. 

BAI Xiao-juanZHAO Xin.   

  1. Department of Geratology,Shengjing Hospital,China Medical University,Shenyang 110001,China
  • Online:2014-01-01 Published:2014-01-04

阿司匹林与女性血管健康

白小涓赵心   

  1. 作者单位:中国医科大学附属盛京医院干诊老年病科,沈阳 110004
  • 作者简介:白小涓,主任医师、教授、博士生导师。工作于中国医科大学盛京医院干诊科。兼任中国老年学学会心脑血管病专业委员会常务委员、中国病理生理学会动脉粥样硬化专业委员会常务委员、中国医师协会心血管内科医师分会委员、中华医学会心血管分会女性健康学组委员、中华医学会老年医学分会老年心血管病学组委员、中国老年保健医学研究会老年心血管病分会委员。

Abstract:

In last century,aspirin became a standard drug for the secondary prevention of cardiovascular disease.In recent years,a number of clinical trial evidence has confirmed that aspirin had been used as the primary prevention of cardiovascular disease.The mechanism is to block the thromboxane A2 formation by inhibiting cycloosygenase.Studies have shown that low-dose aspirin could effectively reduce coronary heart disease and ischemic stroke risk in males.However,for women,aspirin for primary prevention of coronary heart disease is unobvious.In this paper,we discuss the relationship between aspirin and heart health in females by retrospectively reviewing the mechanism of aspirin,its efficacy and primary prevention effect on cardiovascular disease.

Key words: aspirin, primary prevention, coronary heart disease, women

摘要:

阿司匹林是20世纪心血管病二级预防的标准药物。近年众多临床试验表明,阿司匹林已经作为心血管疾病一级预防的药物之一,其机制是通过抑制环氧化酶而阻断血栓素A2的形成,从而达到抗血小板聚集及预防血栓形成的作用。研究表明,小剂量阿司匹林能有效降低男性冠心病和缺血性卒中的风险。但对女性来说,阿司匹林对冠心病一级预防的获益并不明显,文章通过对阿司匹林的作用机制、疗效、一级预防作用及在计入治疗后的应用等几个方面的回顾,来探讨阿司匹林与女性心脏健康的关系。

关键词: 阿司匹林, 一级预防, 冠心病, 女性

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