关键词: 纳米羟基磷灰石/胶原复合材料, 骨缺损, 仿生矿化, 生物降解性

Abstract: Inflammation，trauma，tumors，congenital malformations，and periodontitis can cause oral bone tissue loss. Bone grafting or increasing bone mass are currently the main methods for repairing oral bone defects. The ideal bone repair material should have good biocompatibility，osteoinduction，osteoconductivity and osteogenic properties. Autogenous bones have limited sources，and allogeneic bones have problems such as immune rejection，cross-infection of diseases，etc. Therefore，the development of ideal bone repair materials is currently a research focus in the field of stomatology field. Nano-hydroxyapatite / collagen composites （nHAC）are prepared through in vitro biomimetic mineralization process，and have the same chemical composition and layered structure as natural bone tissue，being with good biocompatibility，osteoconductivity，osteoinduction and biodegradation，so they are widely studied and used. In this paper，the composition，properties，clinical application and research progress of nHAC are reviewed through analysis of relevant literatures，which lays a foundation for its clinical application.

Key words: Nano-hydroxyapatite/collagen composite, nHAC；bone defect；biomimetic mineralization；biodegradability