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Chinese Journal of Practical Gynecology and Obstetrics ›› 2013, Vol. 9 ›› Issue (6) : 415-419.

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Abstract

Abstract：The diagnosis of hyperthyroidism is confirmed by elevated serum free thyroxine (FT4) and decreased TSH(<0.1 mU/L). Graves disease，the most common cause of hyperthyroidism during pregnancy，is characterized by a typical goiter，and presence of TSH receptor antibodies (TRAb).TRAb could cross the placenta and stimulate the fetal thyroid.Antithyroid drug therapy (ATD)，including propylthiouracil (PTU)and methimazole(MMI)，has been used to maintain FT4 in the upper limit of the normal reference range.PTU should be limited in the first trimester for its potential liver toxicity，while MMI should be used after the first trimester for its teratogenicity. ATD should be adjustmented according to the serum FT4 level to avoid side effects to the fetus.Postpartum ATD treatment cause little harm to the baby.

Key words

hyperthyroidism；Graves disease；antithyroid drug therapy / pregnancy

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