There is no effective medical therapy to date. GnRHa are useful preoperatively. Aromatase inhibitors and SERM may be useful in postmenopausal woman with symptomatic myoma. Lowdose mifepristone is a relatively cheap drug with minimal sideeffects. The use of Levonorgestrelreleasing intrauterine system has been shown to reduce menstrual blood loss with idiopathic menorrhagia or menorrhagia due to leiomyomas.