The role of SREBP1 in the oncogenesis and development of cervical cancer.
ZHANG Zhan-xin，LOU Xue-ling，YAO Li.
Chinese Journal of Practical Gynecology and Obstetrics ›› 2015, Vol. 31 ›› Issue (7) : 660-663.
The role of SREBP1 in the oncogenesis and development of cervical cancer.
Abstract： Objective To research the expressions of SREBP1 in cervical cancer and explore the significances of SREBP1 in oncogenesis and development of cervical cance. Methods A total of 100 cervical samples were collected from Department of Gynaecology, Zhengzhou People's Hospital (from Jan. 2010 to Jan. 2015), including 50 cervical cancer tissues and 50 cervical noncancer tissues of the same donor as controls. The expression of SREBP1 in cervical cancer tissues and in the paired cervical noncancer tissues was evaluated by RT-PC. Its correlation with the clinicopathological parameters including tumor grade and stage was subjected to statistical analysis.Results RT-PCR showed that SREBP1 mRNA levels were significantly increased in cervical tumors（0.60±0.18 vs. 0.13±0.04，P<0.01）. Additionally， the expression levels of SREBP1 mRNA were correlated with clinical stages and tumor grade significantly（P<0.05），however,there was no correlation of SREBP1 expression with the patient’s age， tumor size and tumor type. In cervical cancer group，there was a positive correlation between SREBP1 mRNA expression and FASN mRNA expression （r=0.705，P<0.05）. Conclusion SREBP1 may play an important role in oncogenesis and development of cervical cancer，which may become new potential targets for clinical treatment of cervical cancer.
cervical cancer / sterol regulatory element binding protein1 / fatty acid synthase
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（2015-02-04收稿 2015-04-05修回）
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