Abstract:Objective To assess prognostic factors impacted on overall survival in patients with epithelial ovarian carcinoma．Methods Totally 160 patients with stages I-IV epithelial ovarian carcinoma admitted in Liao-ning Provincial Cancer Hospital from Jan. 2006 to Dec. 2007 were analyzed by retrospective analysis．Results The prognosis of epithelial ovarian carcinomas were related to the number of labors，stage, peritoneal metastasis, the size of residues lesions, the number of courses of chemotherapy, sensitivity to platinum and the level of CA125 after 2-3 courses of chemotherapy (P<0．05).Compared with stage Ⅳ, the risk of mortality was 0.164 for stage Ⅰ(95%CI 0.035-0.775),0.175 for stage Ⅱ(95%CI 0.037-0.820),0.359 (95%CI 0.184-0.704 ) for stage Ⅲ ([WTBX]P[WTBZ]<0.05). The risk of mortality was 0.368，(95%CI 0.209~0.647) for the patients received ≥6 courses of chemotherapy,in comparison with patients received ＜6 courses of chemotherapy（P<0.01）.The risk of mortality in the patients insensitive to platinum was 4.434 times higher than that in patients sensitive to platinum (95%CI 2.454-8.012, P<0.01). The risk of mortality in the patients of serum CA125＞35 kU/L after 2-3 courses of chemotherapy was 2.062 times higher than that in patients CA125≤35 kU/L (95%CI 1.190-3.572,[WTBX]P[WTBZ]=0.01).Conclusion The major independent prognostic factor of epithelial ovarian carcinoma is stage， the number of course of chemotherapy，sensitivity to platinum and the level of CA125 after 2-3 courses of chemotherapy.