双胎妊娠期运动与母儿健康的研究进展

Chinese Journal of Practical Gynecology and Obstetrics ›› 2026, Vol. 42 ›› Issue (6) : 668-672.

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Chinese Journal of Practical Gynecology and Obstetrics ›› 2026, Vol. 42 ›› Issue (6) : 668-672. DOI: 10.19538/j.fk2026060119

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Bone JN, Joseph KS, Magee LA, et al. Obesity, twin pregnancy, and the role of assisted reproductive technology[J]. JAMA Netw Open, 2024, 7(1):e2350934. DOI: 10.1001/jamanetworkopen.2023.50934.
The prevalence of overweight and obesity (body mass index [BMI] ≥25) has increased globally, and high BMI has been linked to higher rates of twin birth. However, evidence from large population-based studies is lacking; the issue needs careful study, as women with obesity are also more likely to use assisted reproductive technology (ART), which frequently results in twin pregnancy.
[2]
Marleen S, Kodithuwakku W, Nandasena R, et al. Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies[J]. Hum Reprod Update, 2024, 30(3):309-322. DOI: 10.1093/humupd/dmae002.
ART is associated with higher rates of twin pregnancies than singleton pregnancies. Whether twin pregnancies conceived following ART have additional maternal and neonatal complications compared with non-ART twin pregnancies is not known.
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Chen P, Li M, Mu Y, et al. Temporal trends and adverse perinatal outcomes of twin pregnancies at differing gestational ages: an observational study from China between 2012-2020[J]. BMC Pregnancy Childbirth, 2022, 22(1): 467. DOI: 10.1186/s12884-022-04766-0.
With the development of assisted reproductive technology, the twinning rate in China has been increasing. However, little is known about twinning from 2014 onwards. In addition, previous studies analysing optimal gestational times have rarely considered maternal health conditions. Therefore, whether maternal health conditions affect the optimal gestational time remains unclear.
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Multifetal Gestations :Twin,Triplet,and Higher-Order Multifetal Pregnancies:ACOG Practice Bulletin, Number 231[J]. Obstet Gynecol, 2021, 137(6): e145-e162.
The incidence of multifetal gestations in the United States has increased dramatically over the past several decades. For example, the rate of twin births increased 76% between 1980 and 2009, from 18.9 to 33.3 per 1,000 births (1). However, after more than three decades of increases, the twin birth rate declined 4% during 2014-2018 to 32.6 twins per 1,000 total births in 2018 (2). The rate of triplet and higher-order multifetal gestations increased more than 400% during the 1980s and 1990s, peaking at 193.5 per 100,000 births in 1998, followed by a modest decrease to 153.4 per 100,000 births by 2009 (3). The triplet and higher-order multiple birth rate was 93.0 per 100,000 births for 2018, an 8% decline from 2017 (101.6) and a 52% decline from the 1998 peak (193.5) (4). The long-term changes in the incidence of multifetal gestations has been attributed to two main factors: 1) a shift toward an older maternal age at conception, when multifetal gestations are more likely to occur naturally, and 2) an increased use of assisted reproductive technology (ART), which is more likely to result in a multifetal gestation (5).
[5]
赵扬玉, 孟新璐, 吴天晨. 双胎妊娠管理的现状、挑战与展望[J]. 中国实用妇科与产科杂志, 2025, 41(2): 129-132.DOI: 10.19538/j.fk2025020101.
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邹馨逸, 李闯, 魏军. 双胎妊娠的孕期管理与分娩[J]. 中国实用妇科与产科杂志, 2025, 41(2): 133-138.DOI: 10.19538/j.fk2025020102.
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Campbell M, Koegl J, Bone JN, et al. Differences in risk factors for severe Preeclampsia and HELLP syndrome in singleton versus twin pregnancies: A Population-Based Cohort Study[J]. BJOG, 2025. DOI: 10.1111/1471-0528.18351.
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Poprzeczny AJ, Deussen AR, Mitchell M, et al. Antenatal physical activity interventions and pregnancy outcomes: A systematic review and meta-analysis with a focus on trial quality[J]. BJOG, 2025, 132(6): 709-723. DOI: 10.1111/1471-0528.18084.
Guidelines recommending regular physical activity in pregnancy for improving pregnancy outcomes are informed by published meta‐analyses. Inclusion of randomised trials of poor methodological quality may bias effect estimates.
[9]
Barakat R, Silva-Jose C, Zhang D, et al. Influence of physical activity during pregnancy on maternal hypertensive disorders: A systematic review and meta-analysis of randomized controlled trials[J]. J Pers Med, 2023, 14(1):10. DOI: 10.3390/jpm14010010.
Gestational hypertension is a notable concern with ramifications for maternal and fetal health. Preemptive measures, including physical activity (PA), are crucial. There is a pressing need for comprehensive investigations into the impact of various forms of PA on hypertensive disorders. A systematic review and meta-analysis (CRD42022372468) following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed. Our review exclusively considered randomized clinical trials (RCTs) between 2010 and 2023, using the following databases: EBSCO, including Academic Search Premier, Education Resources Information Center, PubMed/MEDLINE, SPORTDiscus, and OpenDissertations; Clinicaltrials.gov; Web of Science; Scopus; the Cochrane Database of Systematic Reviews; and the Physiotherapy Evidence Database (PEDro). The primary outcome was hypertensive disorders occurring during pregnancy (14 studies). Diagnosed preeclampsia (15 studies) and blood pressure levels were also examined (17 studies). PA during pregnancy was significantly associated with a reduced risk of hypertensive disorders (RR = 0.44, 95% CI = 0.30, 0.66). The data also indicate a positive correlation between PA during pregnancy and both systolic (MD = −2.64, 95% CI = −4.79, −0.49) and diastolic (MD = −1.99, 95% CI = −3.68, −0.29) blood pressure levels. The relationship between PA and the incidence of diagnosed preeclampsia did not demonstrate a statistically significant association (RR = 0.81, 95% CI = 0.59, 1.11; p = 0.20). Random effects were used for all analyses. PA during pregnancy promises to improve maternal health by reducing the risk of gestational hypertension and positively affecting systolic and diastolic blood pressure.
[10]
Huifen Z, Yaping X, Meijing Z, et al. Effects of moderate-intensity resistance exercise on blood glucose and pregnancy outcome in patients with gestational diabetes mellitus: A randomized controlled trial[J]. J Diabetes Complications, 2022, 36(5): 108186. DOI: 10.1016/j.jdiacomp.2022.108186.
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Sánchez-Polán M, Nagpal TS, Zhang D, et al. The influence of physical activity during pregnancy on maternal pain and discomfort: A meta-analysis[J]. J Pers Med, 2023, 14(1):44. DOI: 10.3390/jpm14010044.
Pregnant women may experience pain and discomfort during pregnancy, especially in areas such as the lower back and pelvic girdle. Pain in pregnancy is associated with poor quality of life, and because it is a common occurrence, pregnant women may be offered several resources to prevent discomforts throughout pregnancy, such as engaging in physical activity. This study was a meta-analysis of randomised controlled trials (prospectively registered in Prospero, registration number: CRD42023451320) aimed to assess the effects of physical activity during pregnancy on maternal pain and discomfort. We analysed 16 randomised clinical trials. The results of these analyses indicate that women who performed physical activity had significantly less intensity of pain (z = <2.69, p = <0.007; SMD = −0.66, 95% CI = −1.13, −0.18, I2 = <91%, Pheterogeneity = <0.001) and a reduction observed in the disability questionnaire (z = <2.37, p = <0.02; SMD = −0.80, 95% CI = −1.47, −0.14, I2 = <91%, Pheterogeneity = <0.001), and overall reduced general pain (z = <3.87, p = <0.001; SMD = −0.56, 95% CI = −0.84, −0.27, I2 = <86%, Pheterogeneity = <0.001) than women who did not practice physical activity during pregnancy. In conclusion, physical activity during pregnancy could effectively help to diminish pain intensity, reduce disability due to pain, and generally reduce pain.
[12]
Meah VL, Davies GA, Davenport MH. Why can't I exercise during pregnancy? Time to revisit medical 'absolute' and 'relative' contraindications: systematic review of evidence of harm and a call to action[J]. Br J Sports Med, 2020, 54(23): 1395-1404. DOI: 10.1136/bjsports-2020-102042.
Clinical guidelines recommend pregnant women without contraindication engage in regular physical activity. This is based on extensive evidence demonstrating the safety and benefits of prenatal exercise. However, certain medical conditions or contraindications warrant a reduction, modification or cessation of activity due to potential health risks.
[13]
Kwiatkowska K, Kosińska-Kaczyńska K, Walasik I, et al. Physical activity patterns of women with a twin pregnancy-a cross-sectional study[J]. Int J Environ Res Public Health, 2021, 18(15): 7724. DOI: 10.3390/ijerph18157724.
Background: No specific physical activity guidelines are available for women in multiple pregnancy. Aim of the study was to assess the knowledge and experience of women regarding physical activity during their latest twin pregnancy. Methods: A cross-sectional study including women after a twin delivery was conducted in Poland. A questionnaire was distributed in 2018 via web pages and Facebook groups designed for pregnant women. Results: 652 women filled out the questionnaire completely. Only 25% of women performed any physical exercises during twin gestation. The frequency of preterm delivery was similar in physically active and non-active participants. 35% of the respondents claimed to have gained information on proper activity from obstetricians during antenatal counselling while 11% claimed to be unable to identify the reliable sources of information. 7% of women admitted to feel discriminated by social opinion on exercising during a twin pregnancy. Conclusions: The population of women with a twin gestation is not sufficiently physically active and is often discouraged from performing exercises during gestation. Therefore, it is crucial to inform obstetricians to recommend active lifestyle during a twin gestation and to provide reliable information on physical activity to pregnant women. Further research on this topic is necessary in order for obstetric providers to counsel women on appropriate exercise with a twin pregnancy.
[14]
Dinu M, Napoletano A, Giangrandi I, et al. Exploring basal metabolic rate and dietary adequacy in twin pregnancies: the VENERE study[J]. Nutr Metab (Lond), 2024, 21(1):99. DOI: 10.1186/s12986-024-00881-1.
[15]
Wierzejska RE. Review of dietary recommendations for twin pregnancy: Does nutrition science keep up with the growing incidence of multiple gestations?[J]. Nutrients, 2022, 14(6):1143. DOI: 10.3390/nu14061143.
Recommendations for nutrition and the use of dietary supplements for pregnant women are updated on regular basis but it remains to be seen to what extent they may be applicable in twin pregnancies. The aim of this narrative review is to present the current state of knowledge about the energy and nutrient demand in twin pregnancy. There is general consensus in literature that the energy demand is higher than in a singleton pregnancy, but there is a lack of position statements from scientific societies on specific energy intake that is required. In turn, recommended maternal weight gain, which favors the normal weight of the neonate, has been determined. There is even a larger knowledge gap when it comes to vitamins and minerals, the body stores of which are theoretically used up faster. The greatest number of studies so far focused on vitamin D, and most of them concluded that its concentration in maternal blood is lower in twin as compared to singleton pregnancy. Few randomized studies focus on iron supplementation and there are no other studies that would assess dietary interventions. In light of a growing incidence of multiple pregnancies, more studies are necessary to establish the nutritional demands of the mother and the course of action for adequate supplementation.
[16]
Bodnar LM, Himes KP, Abrams B, et al. Gestational weight gain and adverse birth outcomes in twin pregnancies[J]. Obstet Gynecol, 2019, 134(5): 1075-1086. DOI: 10.1097/AOG.0000000000003504.
To evaluate the association between gestational weight gain in twin pregnancies and small-for-gestational-age (SGA) and large-for-gestational-age (LGA) birth, preterm birth before 32 weeks of gestation, cesarean delivery, and infant death within each prepregnancy body mass index (BMI) category.Data in this population-based study came from Pennsylvania-linked infant birth and death records (2003-2013). We studied 54,836 twins born alive before 39 weeks of gestation. Total pregnancy weight gain (kg) was converted to gestational age-standardized z scores. Multivariable modified Poisson regression models stratified by prepregnancy BMI were used to estimate associations between z scores and outcomes. A probabilistic bias analysis, informed by an internal validation study, evaluated the effect of BMI and weight gain misclassification.Gestational weight gain z score was negatively associated with SGA and positively associated with LGA and cesarean delivery in all BMI groups. The relation between weight gain and preterm birth was U-shaped in nonobese women. An increased risk of infant death was observed for very low weight gain among normal-weight women and for high weight gain among women without obesity. Most excess risks of these outcomes were observed at weight gains at 37 weeks of gestation that are equivalent to less than 14 kg or more than 27 kg in underweight or normal-weight women, less than 11 kg or more than 28 kg in overweight women, and less than 6.4 kg or more than 26 kg in women with obesity. The bias analysis supported the validity of the conventional analysis.Very low or very high weight gains were associated with the adverse outcomes we studied. If the associations we observed are even partially reflective of causality, targeted modification of pregnancy weight gain in women carrying twins might improve pregnancy outcomes.
[17]
Physical Activity and Exercise During Pregnancy and the Postpartum Period: ACOG Committee Opinion, Number 804[J]. Obstet Gynecol, 2020, 135(4): e178-e188. DOI: 10.1097/AOG.0000000000003772.
Exercise, defined as physical activity consisting of planned, structured, and repetitive bodily movements done to improve one or more components of physical fitness, is an essential element of a healthy lifestyle, and obstetrician–gynecologists and other obstetric care providers should encourage their patients to continue or to commence exercise as an important component of optimal health. Women who habitually engaged in vigorous-intensity aerobic activity or who were physically active before pregnancy can continue these activities during pregnancy and the postpartum period. Observational studies of women who exercise during pregnancy have shown benefits such as decreased gestational diabetes mellitus, cesarean birth and operative vaginal delivery, and postpartum recovery time. Physical activity also can be an essential factor in the prevention of depressive disorders of women in the postpartum period. Physical activity and exercise in pregnancy are associated with minimal risks and have been shown to benefit most women, although some modification to exercise routines may be necessary because of normal anatomic and physiologic changes and fetal requirements. In the absence of obstetric or medical complications or contraindications, physical activity in pregnancy is safe and desirable, and pregnant women should be encouraged to continue or to initiate safe physical activities. This document has been revised to incorporate recent evidence regarding the benefits and risks of physical activity and exercise during pregnancy and the postpartum period.
[18]
Östgaard HC, Andersson GBJ, Schultz AB. Influence of some biomechanical factors on low-back pain in pregnancy[J]. Spine, 1993, 18(1): 61-65. DOI:10.1097/00007632-199301000-00010.
Several biomechanical factors were recorded intermittently in 855 pregnant women from the 12th to the 36th week of gestation and were related to back pain occurrence during pregnancy. The three factors related to the development of back pain were abdominal sagittal diameter, which correlated with back pain, with a coefficient of 0.15 (P < 0.01); transverse diameter (r = 0.13, P < 0.01); and depth of the lumbar lordosis, which correlated with a coefficient of 0.11 (P < 0.01). In the group of women who were pregnant for their first time, there was a significantly lower peripheral joint laxity in the 12th week in those women who, later in pregnancy, developed back pain. These correlations suggest that back pain in pregnancy can not be explained primarily by biomechanical factors.
[19]
Lipworth H, Melamed N, Berger H, et al. Maternal weight gain and pregnancy outcomes in twin gestations[J]. Am J Obstet Gynecol, 2021, 225(5): 532. e1-e12. DOI: 10.1016/j.ajog.2021.04.260.
[20]
Damen L, Buyruk HM, Güler-Uysal F, et al. Pelvic pain during pregnancy is associated with asymmetric laxity of the sacroiliac joints[J]. Acta Obstet Gynecol Scand, 2001, 80(11): 1019-1024. DOI: 10.1034/j.1600-0412.2001.801109.x.
[21]
Bdolah Y, Lam C, Rajakumar A, et al. Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia[J]. Am J Obstet Gynecol, 2008, 198(4): 428. e1-6. DOI: 10.1016/j.ajog.2007.10.783.
[22]
Sivan E, Maman E, Homko CJ, et al. Impact of fetal reduction on the incidence of gestational diabetes[J]. Obstet Gynecol, 2002, 99(1): 91-94. DOI: 10.1016/s0029-7844(01)01661-1.
To estimate the rate of gestational diabetes in triplet pregnancies and to assess the impact of fetal reduction on the incidence of this complication.One hundred eighty-eight consecutive triplet pregnancies referred to the Sheba Medical Center between 1994 and 1998 were included. One hundred three of these pregnancies continued as triplets, whereas 85 women elected to undergo fetal reduction to twins. The incidence of gestational diabetes (based on the criteria of Carpenter and Coustan) and other outcome variables were compared between the two groups. Student t-tests and chi(2) analysis were used as appropriate.Mean (+/-SD) maternal age was 29.2 +/- 4.8 in the triplet group and 29.3 +/- 4.1 in the reduction group. The groups had similar median parity (1.6 +/- 1.1 in the triplet group and 1.5 +/- 0.7 in the reduction group). The rate of gestational diabetes was significantly higher in the triplet group than in the reduction group (22.3% vs 5.8%). A lower birth weight (1764 +/- 448 g vs 2208 +/- 526 g) and an earlier gestational age at delivery (33.4 +/- 2.8 weeks vs 36.0 +/- 2.8 weeks) were observed in the triplet group compared with the reduction group.The number of fetuses in multifetal pregnancies influences the incidence of gestational diabetes. These findings support the hypothesis that an increase in placental mass and, thus, an increase in diabetogenic hormones play a role in the etiology of gestational diabetes.
[23]
Wang W, Wen L, Zhang Y, et al. Maternal prenatal stress and its effects on primary pregnancy outcomes in twin pregnancies[J]. J Psychosom Obstet Gynaecol, 2020, 41(3): 198-204. DOI: 10.1080/0167482X.2019.1611776.
[24]
Zhou Y, Huang J, Baker PN, et al. The prevalence and associated factors of prenatal depression and anxiety in twin pregnancy: a cross-sectional study in Chongqing, China[J]. BMC Pregnancy Childbirth, 2022, 22(1): 877. DOI: 10.1186/s12884-022-05203-y.
Pregnant women expecting twins are more likely to experience stress, which can lead to anxiety and depression. Our aim was to investigate the prevalence of prenatal anxiety and depressive symptoms in women with twin pregnancies and the associated factors.
[25]
黎海婷, 陈秋和, 单丹, 等. 营养运动治疗在妊娠期高血糖中的应用[J]. 中国实用妇科与产科杂志, 2025, 41(4):411-414.DOI:10.19538/j.fk2025040108.
[26]
Mitro SD, Peddada S, Gleason JL, et al. Longitudinal changes in physical activity during pregnancy: national institute of child health and human development fetal growth studies[J]. Med Sci Sports Exerc, 2022, 54(9): 1466-1475. DOI: 10.1249/MSS.0000000000002947.
Exercise in pregnancy is associated with many perinatal benefits, but patterns of home, work, and commuting activity are not well described. We investigated longitudinal activity in singleton and twin pregnancy by activity domain and maternal characteristics.
[27]
Meah VL, Strynadka MC, Khurana R, et al. Physical activity behaviors and barriers in multifetal pregnancy: what to expect when you're expecting more[J]. Int J Environ Res Public Health, 2021, 18(8): 3907. DOI: 10.3390/ijerph18083907.
The health benefits of prenatal physical activity (PA) are established for singleton pregnancies. In contrast, individuals with multifetal pregnancies (twins, triplets or more) are recommended to restrict or cease PA. The objectives of the current study were to determine behaviors and barriers to PA in multifetal pregnancies. Between 29 May and 24 July 2020, individuals with multifetal pregnancies participated in an online survey. Of the 415 respondents, there were 366 (88%) twin, 45 (11%) triplet and 4 (1%) quadruplet pregnancies. Twenty-seven percent (n = 104/388) of respondents completed no PA at all during pregnancy, 57% (n = 220/388) completed PA below current recommendations, and 16% (n = 64/388) achieved current recommendations (150-min per week of moderate-intensity activity). Most respondents (n = 314/363 [87%]) perceived barriers to PA during multifetal pregnancy. The most prominent were physical symptoms (n = 204/363 [56%]) and concerns about risks to fetal wellbeing (n = 128/363 [35%]). Sixty percent (n = 92/153) felt that these barriers could be overcome but expressed the need for evidence-based information regarding PA in multifetal pregnancy. Individuals with multifetal pregnancies have low engagement with current PA recommendations but remain physically active in some capacity. There are physical and psychosocial barriers to PA in multifetal pregnancy and future research should focus on how these can be removed.
[28]
Zemet R, Schiff E, Manovitch Z, et al. Quantitative assessment of physical activity in pregnant women with sonographic short cervix and the risk for preterm delivery: A prospective pilot study[J]. PLoS One, 2018, 13(6): e0198949. DOI: 10.1371/journal.pone.0198949.
[29]
Gao L, Lyu SP, Zhao XR, et al. Systematic management of twin pregnancies to reduce pregnancy complications[J]. Chin Med J, 2020, 133(11): 1355-1357. DOI: 10.1097/CM9.0000000000000808.
[30]
Kovacevich GJ, Gaich SA, Lavin JP, et al. The prevalence of thromboembolic events among women with extended bed rest prescribed as part of the treatment for premature labor or preterm premature rupture of membranes[J]. Am J Obstet Gynecol, 2000, 182(5): 1089-1092. DOI: 10.1067/mob.2000.105405.
This study was undertaken to determine the prevalence of thromboembolic events among women with extended bed rest prescribed as part of the treatment of premature labor or preterm premature rupture of membranes.A retrospective chart review was undertaken of all women who had bed rest of >/=3 days' duration prescribed as part of the treatment of premature labor or preterm premature rupture of membranes in the Akron General Medical Center Perinatal Unit during the period January 1, 1997-December 31, 1998. The prevalence of thromboembolic events in this population was determined. The charts of all additional gravid women with antepartum or postpartum deep vein thrombosis or pulmonary embolism diagnosed during the study period were also reviewed. The prevalence of these disorders among the pregnant population for whom extended bed rest was not prescribed as part of the treatment of premature labor or preterm premature rupture of membranes was also calculated. Statistical comparison of the prevalences in the 2 populations was undertaken by means of the chi(2) analysis with the Fisher exact test.There were 192 patients admitted during the study period who had extended bed rest prescribed as part of the treatment of premature labor or preterm premature rupture of membranes. Three of these women had thromboembolic events, for a prevalence of 15.6 cases per 1000 women. Five additional gravid women were admitted for the treatment of deep vein thrombosis or pulmonary embolism. There were 6164 deliveries among women not treated with extended bed rest for premature labor or preterm premature rupture of membranes during this period. Thus the prevalence of these phenomena among the remaining pregnant women was 0.8 cases per 1000 women. The prevalences of these disorders in the 2 populations were highly significantly different.The prevalence of thromboembolic events among women for whom extended bed rest is prescribed as part of the treatment of premature labor or preterm premature rupture of membranes is significantly increased with respect to that among gravid women who do not receive this therapy and is substantially higher than previously reported. If this finding is confirmed in other populations, it may be prudent to undertake further studies to determine whether this prevalence can be reduced.
[31]
Promislow JH, Hertz-Picciotto I, Schramm M, et al. Bed rest and other determinants of bone loss during pregnancy[J]. Am J Obstet Gynecol, 2004, 191(4): 1077-1083. DOI: 10.1016/j.ajog.2004.05.058.
The purpose of this study was to evaluate patterns of bone loss during pregnancy and potential influences.This was a prospective study of 181 women receiving prenatal care at Magee-Womens Hospital or its auxiliary clinics in Pittsburgh, Pennsylvania, between 1992 and 1995. Bone mineral density was measured at approximately 16 and 36 weeks' gestation.Trabecular, but not cortical, bone loss occurred during pregnancy. Mean ultra-distal bone mineral density loss was 1.9% (95% CI 1.2-2.5) during the 20-week period. Women prescribed bed rest had an adjusted mean loss of 4.6% compared with 1.5% for women not prescribed bed rest (P =.001) and 6-fold higher odds (P =.001) of bone loss > or =5% during the 20-week period. Nulliparity, calcium intake < 2 000 mg/day, low weight gain, and maternal age < 21 or >30 years were more modestly associated with greater bone loss.Substantial trabecular bone loss may occur during pregnancy, particularly in women prescribed bed rest. Study of postpartum bone recovery in such women is needed.
[32]
Maloni JA, Alexander GR, Schluchter MD, et al. Antepartum bed rest: maternal weight change and infant birth weight[J]. Biol Res Nurs, 2004, 5(3): 177-186. DOI: 10.1177/1099800403260307.
Despite lack of evidence for effectiveness, obstetricians in the United States prescribe antepartum bed rest for more than 700,000 women per year. However, in nonpregnant samples, bed rest treatment produces weight loss. This study assessed maternal weight change (gain) during antepartum hospitalization for bed rest treatment; compared appropriateness of infant birth weights for gestational age, race, and gender; and determined whether maternal weight change predicted infant birth weight. The convenience sample for this longitudinal study consisted of 141 women with high-risk pregnancies who were treated with hospital bed rest. Weekly rate of pregnancy weight change by body mass index was compared with Institute of Medicine recommendations for rate of pregnancy weight gain. Infant birth weight was compared with current US infant birth weights for matching gestational age, gender, and race. Weekly antepartum weight change was significantly lower than Institute of Medicine recommendations (P < 0.001). Infant birth weights were also significantly lower than the national mean when matched for each infant's gestational age, race, and gender (P < 0.001). Maternal weight change predicted infant birth weight (P = 0.05). Bed rest treatment is ineffective for improving pregnancy weight gain. Lower infant birth weights across all gestational ages suggest that maternal weight loss during bed rest may be associated with an increased risk of fetal growth restriction. A randomized trial comparing women with high-risk pregnancies who are ambulatory with those on bed rest is needed to determine whether bed rest treatment, underlying maternal-fetal disease, or both influence inadequate maternal weight gain and poor intrauterine growth.
[33]
May KA. Impact of prescribed activity restriction during pregnancy on women and families[J]. Health Care Women Int, 2001, 22(1-2): 29-47. DOI: 10.1080/073993301300003063.
Using grounded theory, I examined the experience of women and their families of prescribed activity restriction during pregnancy for treatment of preterm labor. The major finding in this study suggests that women and their families see themselves as "doing the best we can" as they attempt to balance the demands of activity restriction and the needs of individuals and the family. Invariably, maternal activity restriction resulted in increased emotional distress and, in some cases, family disruption. Those who succeeded in establishing a balance between these competing demands saw themselves as "doing okay" and found the emotional distress and family disruption to be manageable. In contrast, those who had difficulty balancing competing demands described themselves as "on the edge" and experienced uncomfortable levels of emotional distress and, occasionally. significant disruptions to the family. Conditions associated with these two modes of functioning, as well as consequences of this experience for women and their families, are identified.
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da Silva Lopes K, Takemoto Y, Ota E, et al. Bed rest with and without hospitalisation in multiple pregnancy for improving perinatal outcomes[J]. Cochrane Database Syst Rev, 2017, 3(3): CD012031. DOI: 10.1002/14651858.CD012031.pub2.
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SMA statement the benefits and risks of exercise during pregnancy. Sport Medicine Australia[J]. J Sci Med Sport, 2002, 5(1): 11-9. DOI: 10.1016/s1440-2440(02)80293-6.
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Bull FC, Al-Ansari SS, Biddle S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour[J]. Br J Sports Med, 2020, 54(24): 1451-1462. DOI: 10.1136/bjsports-2020-102955.
To describe new WHO 2020 guidelines on physical activity and sedentary behaviour.
[38]
Piercy KL, Troiano RP, Ballard RM, et al. The Physical Activity Guidelines for Americans[J]. JAMA, 2018, 320(19): 2020-2028. DOI: 10.1001/jama.2018.14854.
Approximately 80% of US adults and adolescents are insufficiently active. Physical activity fosters normal growth and development and can make people feel, function, and sleep better and reduce risk of many chronic diseases.To summarize key guidelines in the Physical Activity Guidelines for Americans, 2nd edition (PAG).The 2018 Physical Activity Guidelines Advisory Committee conducted a systematic review of the science supporting physical activity and health. The committee addressed 38 questions and 104 subquestions and graded the evidence based on consistency and quality of the research. Evidence graded as strong or moderate was the basis of the key guidelines. The Department of Health and Human Services (HHS) based the PAG on the 2018 Physical Activity Guidelines Advisory Committee Scientific Report.The PAG provides information and guidance on the types and amounts of physical activity to improve a variety of health outcomes for multiple population groups. Preschool-aged children (3 through 5 years) should be physically active throughout the day to enhance growth and development. Children and adolescents aged 6 through 17 years should do 60 minutes or more of moderate-to-vigorous physical activity daily. Adults should do at least 150 minutes to 300 minutes a week of moderate-intensity, or 75 minutes to 150 minutes a week of vigorous-intensity aerobic physical activity, or an equivalent combination of moderate- and vigorous-intensity aerobic activity. They should also do muscle-strengthening activities on 2 or more days a week. Older adults should do multicomponent physical activity that includes balance training as well as aerobic and muscle-strengthening activities. Pregnant and postpartum women should do at least 150 minutes of moderate-intensity aerobic activity a week. Adults with chronic conditions or disabilities, who are able, should follow the key guidelines for adults and do both aerobic and muscle-strengthening activities. Recommendations emphasize that moving more and sitting less will benefit nearly everyone. Individuals performing the least physical activity benefit most by even modest increases in moderate-to-vigorous physical activity. Additional benefits occur with more physical activity. Both aerobic and muscle-strengthening physical activity are beneficial.The Physical Activity Guidelines for Americans, 2nd edition, provides information and guidance on the types and amounts of physical activity that provide substantial health benefits. Health professionals and policy makers should facilitate awareness of the guidelines and promote the health benefits of physical activity and support efforts to implement programs, practices, and policies to facilitate increased physical activity and to improve the health of the US population.
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Santos-Rocha R, Isabel CG, Szumilewicz A, et al. Exercise Testing and Prescription for Pregnant Women: Evidence-Based Guidelines[M]. Berlin:Springer, 2019.
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Mottola MF, Davenport MH, Ruchat SM, et al. 2019 Canadian guideline for physical activity throughout pregnancy[J]. Br J Sports Med, 2018, 52(21): 1339-1346. DOI: 10.1136/bjsports-2018-100056.
The objective is to provide guidance for pregnant women and obstetric care and exercise professionals on prenatal physical activity. The outcomes evaluated were maternal, fetal or neonatal morbidity, or fetal mortality during and following pregnancy. Literature was retrieved through searches of MEDLINE, EMBASE, PsycINFO, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Scopus and Web of Science Core Collection, CINAHL Plus with Full Text, Child Development & Adolescent Studies, Education Resources Information Center, SPORTDiscus, ClinicalTrials.gov and the Trip Database from inception up to 6 January 2017. Primary studies of any design were eligible, except case studies. Results were limited to English-language, Spanish-language or French-language materials. Articles related to maternal physical activity during pregnancy reporting on maternal, fetal or neonatal morbidity, or fetal mortality were eligible for inclusion. The quality of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation methodology. The Guidelines Consensus Panel solicited feedback from end users (obstetric care providers, exercise professionals, researchers, policy organisations, and pregnant and postpartum women). The development of these guidelines followed the Appraisal of Guidelines for Research and Evaluation II instrument. The benefits of prenatal physical activity are moderate and no harms were identified; therefore, the difference between desirable and undesirable consequences (net benefit) is expected to be moderate. The majority of stakeholders and end users indicated that following these recommendations would be feasible, acceptable and equitable. Following these recommendations is likely to require minimal resources from both individual and health systems perspectives.
[41]
Royal Australian and New Zealand College of Obstetricians and Gynaecologists(RANZCOG)(2020). Exercise in pregnancy[EB/ON].(2020-06-01)[2026-03-11]. https://example.com/Exercise-during-pregnancy.pdf.
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中国妇幼保健协会妊娠合并糖尿病专业委员会, 中华医学会妇产科学分会产科学组. 妊娠期运动专家共识(草案)[J]. 中华围产医学杂志, 2021, 24(9): 641-645. DOI: 10.3760/cma.j.issn113903-20210713-00630.
[43]
中国妇幼保健协会双胎妊娠专业委员会, 国家产科专业医疗质量控制中心. 双胎妊娠孕期生活方式集束化管理预防母体并发症专家共识(2025年版)[J]. 中国实用妇科与产科杂志, 2025, 41(12):1281-1288. DOI: 10.19538/j.fk2025120112.
[44]
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The aim was to analyze the knowledge and experience of women regarding physical activity during their latest pregnancy. An anonymous questionnaire was completed electronically, in 2018, by 9345 women who gave birth at least once, with 52% of the women having performed exercises during pregnancy. Physically non-active respondents suffered from gestational hypertension (9.2% vs. 6.7%; p < 0.01) and gave birth prematurely (9% vs. 7%; p < 0.01) to newborns with a low birth weight significantly more often (6% vs. 3.6%; p < 0.001). Physically active women delivered vaginally more often (61% vs. 55%; p < 0.001) and were more likely to have a spontaneous onset of the delivery as compared with non-active women (73.8% vs. 70.7% p = 0.001). The women who were informed by gynaecologist about the beneficial influence of physical activity during pregnancy exercised significantly more often (67% vs. 44% p < 0.001). In addition, 13% of the women felt discrimination due to their physical activity during a pregnancy, 22% of respondents’ physical activity was not accepted by their environment, and 39.1% of the women were told by others to stop physical exercise because it was bad for the baby’s health. Physical activity during pregnancy is associated with improved fitness, decreased pregnancy ailments occurrence, and therefore influences the course of pregnancy and delivery in a positive way.
[45]
Xie Y, Zhao H, Zhao M, et al. Effects of resistance exercise on blood glucose level and pregnancy outcome in patients with gestational diabetes mellitus: a randomized controlled trial[J]. BMJ Open Diabetes Res Care, 2022, 10(2): e002622. DOI: 10.1136/bmjdrc-2021-002622.
To date, the effects of resistance exercise on diabetes-related parameters (blood glucose level and insulin use) and pregnancy outcome in participants with gestational diabetes mellitus (GDM) have not been compared with those of aerobic exercise. To investigate the effect of resistance exercise versus aerobic exercise on blood glucose level, insulin utilization rate, and pregnancy outcome in patients with GDM.
[46]
Syed H, Slayman T, Thoma DC. ACOG Committee Opinion No. 804: Physical Activity and Exercise During Pregnancy and the Postpartum Period[J]. Obstet Gynecol, 2021, 137(2): 375-376. DOI:10.1097/AOG.0000000000003772.
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U.S. Department of Health and Human Services. Physical activity guidelines for Americans, 2nd edition[M]. New York: HHS, 2018. https://health.gov/sites/default/files/2019-09/Physical_Activity_Guidelines_2nd_edition.pdf,2022.106.
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Gandhi M, Gandhi R, Mack LM, et al. Estimated energy requirements increase across pregnancy in healthy women with dichorionic twins[J]. Am J Clin Nutr, 2018, 108(4): 775-783. DOI: 10.1093/ajcn/nqy184.
Estimated energy requirement (EER) has not been defined for twin pregnancy. This study was designed to determine the EER of healthy women with dichorionic-diamniotic (DCDA) twin pregnancies.We aimed to estimate energy deposition from changes in maternal body protein and fat; to measure resting energy expenditure (REE), physical activity level (PAL), and total energy expenditure (TEE) throughout pregnancy and postpartum; and to define the EER based on the sum of TEE and energy deposition for twin gestation.This is a prospective study of 20 women with DCDA twin gestations. Maternal EER, energy deposition, REE, TEE, and PAL were obtained during the first, second, and third trimesters of pregnancy and immediately postpartum. A mixed-effects linear regression model for repeated measures with random intercept was used to test for the effects of BMI groups and time.Gains in total body protein (mean ± SD: 2.1 ± 0.7 kg) and fat mass (5.9 ± 2.8 kg) resulted in total energy deposition of 67,042 ± 25,586 kcal between 0 and 30-32 weeks of gestation. REE increased 26% from 1392 ± 162 to 1752 ± 172 kcal/d across the 3 trimesters, whereas TEE increased 17% from 2141 ± 283 to 2515 ± 337 kcal/d. Physical activity decreased steadily throughout pregnancy. Reductions in physical activity did not compensate for the rise in REE and energy deposition, thus requiring an increase in dietary energy intake as pregnancy progressed. EER increased 29% from 2257 ± 325 kcal/d in the first trimester to 2941 ± 407 kcal/d in the second trimester, and stayed consistent at 2906 ± 350 kcal/d in the third trimester.Increased energy intake, on average ∼700 kcal/d in the second and third trimesters when compared with the first trimester, is required to support gestational weight gain and the rise in energy expenditure of DCDA twin pregnancies.
[49]
Legendre G, Tassel J, Salomon LJ, et al. Impact of twin gestation on the risk of postpartum stress incontinence[J]. Gynecol Obstet Fertil, 2010, 38(4): 238-243. DOI: 10.1016/j.gyobfe.2010.02.004.
To study twin pregnancy and delivery as a risk factor for developing postpartum stress urinary incontinence (SUI).Retrospective single centre study comparing 117 patients who have delivered twins to 117 patients who have given birth to singletons, between January 2003 and December 2005 in a tertiary maternal-foetal medicine unit. The risk factors associated with the onset of postpartum SUI, its severity, and its impact on the quality of life were studied.Sixty patients in the twin pregnancy group and 59 in the singleton pregnancy group have answered an auto-questionnaire and were included in the study. The medium-term follow-up of the patient was 20.2 months+/-10.1. The prevalence of SUI in the total population was 30%. The rate was significantly higher in the "twin" group (40%) than in the "singleton" group (20%) (p=0.03). Twin gestation was significantly associated with postpartum SUI for more than 20 months after delivery (OR=2.6 [1.1-5.9]). The univariate analysis found six other risk factors: prenatal urinary incontinence (OR=4.2 [1.7-10.4]), BMI greater than 30 (OR=6.3 [1.2-34.1]), labour duration greater than 8h (OR=4.8 [1.6-14.5]), fundal uterine pressure (OR=4.5 [1.1-18.3]), total intrauterine foetal weight (p=0.003), and immediate postpartum urinary incontinence (OR=12.9 [5-33.5]).The vaginal delivery of two successive foetuses does not seem more purveyor of SUI than caesarean. In twin pregnancies, the high rate of postpartum SUI appears to be related to total intrauterine weight.Copyright 2010 Elsevier Masson SAS. All rights reserved.
[50]
中华预防医学会体育运动与健康分会, 中国女医师协会妇产科专业委员会, 北京妇幼保健与优生优育协会, 等. 基于妊娠期盆底功能障碍一级预防策略中国专家共识(2024年版)[J]. 中国实用妇科与产科杂志, 2024, 40(7):737-742.DOI: 10.19538/j.fk2024070114.
[51]
陈逍天, 吴冰, 冯佩, 等. 母亲孕前超重和肥胖与子代先天性心脏病的发生风险:基于江苏省昆山市大样本回顾性队列研究[J]. 中国实用儿科杂志, 2024, 39(2):112-118.DOI:10.19538/j.ek2024020608.
[52]
罗刚, 泮思林, 王思宝, 等. 双胎配对早产儿肺高血压发生的临床资料分析及预后比较[J]. 中国实用儿科杂志, 2024, 39(2):125-129.DOI:10.19538/j.ek2024020610.

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利益冲突 所有作者均声明不存在利益冲突

Funding

National Key Research and Development Program of China(2023YFC2705903)
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