Etiological traceability diagnosis and whole-process management of intrauterine infection in intrapartum fever

HE Yi-xiao; HUANG Zhen-yu; CHEN Dun-jin

doi:10.19538/j.fk2026040106

PDF(935 KB)

Chinese Journal of Practical Gynecology and Obstetrics ›› 2026, Vol. 42 ›› Issue (4) : 406-409. DOI: 10.19538/j.fk2026040106

Etiological traceability diagnosis and whole-process management of intrauterine infection in intrapartum fever

HE Yi-xiao ¹ ,
HUANG Zhen-yu ² ,
CHEN Dun-jin ¹^,³^,⁴^,⁵

Author information +

History +

Abstract

Intrapartum fever is a common emergency in obstetrics. Intrauterine infection （with chorioamnionitis as the core） is the main pathogenic factor，which can significantly increase the risk of adverse outcomes for both the mother and the fetus. Accurate etiological traceability diagnosis and standardized whole-process management are the key to improving prognosis. Based on clinical guidelines and evidence-based medical evidence，this article systematically elaborates on the key points of diagnosis and treatment of intrauterine infection in intrapartum fever，emphasizing the clinical application value of pathogen detection techniques and the importance of multidisciplinary collaboration in order to provide a reference for obstetric clinical practice.

Key words

intrapartum fever / intrauterine infection / etiological traceability diagnosis / whole-process management / chorioamnionitis

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

HE Yi-xiao , HUANG Zhen-yu , CHEN Dun-jin. Etiological traceability diagnosis and whole-process management of intrauterine infection in intrapartum fever[J]. Chinese Journal of Practical Gynecology and Obstetrics. 2026, 42(4): 406-409 https://doi.org/10.19538/j.fk2026040106

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis

[1]	Towers CV, Yates A, Zite N, et al. Incidence of fever in labor and risk of neonatal sepsis[J]. Am J Obstet Gynecol, 2017, 216(6):596.e1-596.e5. DOI:10.1016/j.ajog.2017.02.022. Cited in this article [1]

[2]	王颖, 石慧峰, 杨怡珂, 等. 产时发热的危险因素分析[J]. 中国实用妇科与产科杂志, 2024, 40(10):1036-1041. DOI:10.19538/j.fk2024100115. Cited in this article [1]

[3]	Beck C, Gallagher K, Taylor LA, et al. Chorioamnionitis and Risk for Maternal and Neonatal Sepsis:A Systematic Review and Meta-analysis[J]. Obstet Gynecol, 2021, 137(6):1007-1022. DOI:10.1097/AOG.0000000000004377. Cited in this article [2]

[4]	Goldenberg RL, Hauth JC, Andrews WW. Intrauterine Infection and Preterm Delivery[J]. N Engl J Med, 2000, 342(20):1500-1507. DOI:10.1056/NEJM200005183422007. Cited in this article [1]

[5]	贺雨, 史源. 新生儿脓毒症相关脑损伤的临床特点与发生机制[J]. 中国实用儿科杂志, 2023, 38(5):356-359. DOI:10.19538/j.ek2023050608. Cited in this article [1]

[6]	Hensel D, Zhang F, Carter EB, et al. Severity of intrapartum fever and neonatal outcomes[J]. Am J Obstet Gynecol, 2022, 227(3):513.e1-513.e8. DOI:10.1016/j.ajog.2022.05.031. Cited in this article [2]

[7]	Goetzl L. Maternal fever in labor:etiologies,consequences,and clinical management[J]. Am J Obstet Gynecol, 2023, 228(5S):S1274-S1282. DOI:10.1016/j.ajog.2022.11.002. Cited in this article [2]

[8]	Apuzzio JJ, Williams SF. Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis:Summary of a Workshop[J]. Obstet Gynecol, 2016, 128(1):205-206. DOI:10.1097/AOG.0000000000001497. Cited in this article [1]

[9]

, Ma

. Exploration of fever characteristics in parturients under continuous temperature monitoring during labor analgesia and analysis of the impact on maternal and neonatal outcomes: an observational study[J]. Front Glob Womens Health, 2025, 6:1541227. DOI:10.3389/fgwh.2025.1541227.

Cited in this article [1]

[10]	Patel S, Ciechanowicz S, Blumenfeld YJ, et al. Epidural-related maternal fever:incidence,pathophysiology,outcomes,and management[J]. Am J Obstet Gynecol, 2023, 228(5):S1283-S1304.e1. DOI:10.1016/j.ajog.2022.06.026. Cited in this article [1]

[11]	Stoll BJ, Puopolo KM, Hansen NI, et al. Early-Onset Neonatal Sepsis 2015 to 2017,the Rise of Escherichia coli,and the Need for Novel Prevention Strategies[J]. JAMA Pediatr,2020,174(7):e200593. DOI:10.1001/jamapediatrics.2020.0593. Cited in this article [1]

[12]	中华医学会围产医学分会, 中华医学会妇产科学分会产科学组. 预防围产期B族链球菌病(中国)专家共识[J]. 中华围产医学杂志, 2021, 24(8):561-566. DOI:10.3760/cma.j.cn113903-20210716-00638. Cited in this article [3]

[13]	Szulc W, Szydłowska N, Smyk JM, et al. Progress and Challenges in the Management of Congenital Cytomegalovirus Infection[J]. Clin Pract, 2024, 14(6):2445-2462. DOI:10.3390/clinpract14060191. Cited in this article [1]

[14]	雷敏, 贺芳. 产时发热对母儿结局影响的研究进展[J]中华产科急救电子杂志, 2025, 14(2):119-123. DOI:10.3877/cma.j.issn.2095-3259.2025.02.011. Cited in this article [1]

[15]	Musilova I, Kacerovsky M, Stepan M, et al. Maternal serum C-reactive protein concentration and intra-amniotic inflammation in women with preterm prelabor rupture of membranes[J]. PLOS ONE, 2017, 12(8):e0182731. DOI:10.1371/journal.pone.0182731. Cited in this article [1]

[16]	Gravett MG. Diagnosis of Intra-amniotic Infection by Proteomic Profiling and Identification of Novel Biomarkers[J]. JAMA, 2004, 292(4):462. DOI:10.1001/jama.292.4.462. Cited in this article [1]

[17]	Hochler H, Lipschuetz M, Guedalia J, et al. The impact of peak and duration of maternal intrapartum fever on perinatal outcomes[J]. Am J Obstet Gynecol MFM, 2021, 3(4):100390. DOI:10.1016/j.ajogmf.2021.100390. Cited in this article [1]

[18]

Chiesa

, Pellegrini

, Panero

, et al. C-Reactive

Protein

, Interleukin-6,and Procalcitonin in the Immediate Postnatal Period:Influence of Illness Severity,Risk Status,Antenatal and Perinatal Complications,and Infection[J]. Clin Chem, 2003, 49(1):60-68. DOI:10.1373/49.1.60.

Cited in this article [1]

[19]	邹丽萍. 系统性自身炎症性疾病的神经系统损伤[J]. 中国实用儿科杂志, 2024, 39(6):448-453. DOI:10.19538/j.ek2024060609. Cited in this article [1]

[20]	Keij FM, Achten NB, Tramper-Stranders GA, et al. Stratified Management for Bacterial Infections in Late Preterm and Term Neonates:Current Strategies and Future Opportunities Toward Precision Medicine[J]. Front Pediatr, 2021, 9:590969. DOI:10.3389/fped.2021.590969. Cited in this article [1]

[21]	Kozel TR, Burnham-Marusich AR. Point-of-Care Testing for Infectious Diseases:Past,Present,and Future[J]. J Clin Microbiol, 2017, 55(8):2313-2320. DOI:10.1128/JCM.00476-17. Cited in this article [1]

[22]	Prince AL, Ma J, Kannan PS, et al. The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis[J]. Am J Obstet Gynecol, 2016, 214(5):627.e1-627.e16. DOI:10.1016/j.ajog.2016.01.193. Cited in this article [1]