Objective To identify the risk factors for postpartum outcomes of patients with pregnancy complicated by TOF after cesarean section. Methods A retrospective analysis was conducted on the postpartum outcomes of 42 patients with pregnancy complicated by TOF admitted to Beijing Anzhen Hospital Affiliated to Capital Medical University from May 2011 to May 2020. Logistic regression model was used to identify the risk factors for postpartum outcomes. Results No maternal death occurred; 16 mothers had adverse postpartum outcomes，18（42.86%）had preoperative NYHA cardiac function classification of Ⅲ-Ⅳ，10 （23.81%） had no preoperative TOF surgery，and 12 （28.57%） had percutaneous SpO₂<90% upon admission. No neonatal death or neonatal asphyxia occurred. The study revealed that NYHA cardiac function classification of Ⅲ-Ⅳ（OR=9.43，95% CI 2.21-36.523，P=0.002），no TOF surgery （OR=32.14，95%CI 3.46-298.78，P=0.002），percutaneous SpO₂<90%（OR=9.10，95%CI 1.92-43.19，P=0.005），ventricular septal defect（OR=32.14，95% CI 3.46-298.74，P=0.002），cyanosis （OR=32.14，95%CI 3.46-298.78，P=0.002），and the absence of a multidisciplinary team （MDT）collaboration model （OR=7.00，95%CI 1.72-28.55，P=0.007）were risk factors for adverse postpartum outcomes of patients with pregnancy complicated by TOF. Conclusions No preoperative TOF surgery，complication with ventricular septal defect，preoperative percutaneous SpO₂<90%，and cyanosis seem to be associated with adverse postpartum outcomes. The application of the multidisciplinary diagnosis and treatment model may improve postpartum outcomes.