Objective To compare the perioperative outcomes of laparoendoscopic single-site myomectomy using the "chopstick" technique (cLESS-M) with those of conventional laparoscopic myomectomy (CLS-M). Methods A retrospective analysis was conducted on 255 patients who underwent laparoscopic myomectomy at the First Affiliated Hospital of Army Medical University between August 2018 and April 2020. Patients were divided into the cLESS group (n=117) and the CLS group (n=138) based on the surgical approach. Intraoperative parameters, postoperative recovery indicators, and incidence of perioperative complications were compared between the two groups. Results Baseline data were similar between the two groups (P > 0.05). There were no significant differences in operation time, estimated blood loss, or incidence of perioperative complications. Compared to the CLS group, the cLESS group had a significantly shorter postoperative hospital stay [4.0 (4.0, 5.0) vs. 5.0 (4.0, 6.0) days, P=0.006], lower pain scores at 1 hour postoperatively [2.0 (2.0, 3.0) vs. 3.0 (2.0, 3.0), P < 0.001], and lower pain scores at 24 hours after operation[1.0 (1.0, 1.0) vs. 1.0 (1.0, 2.0), P=0.008]. Conclusion The cLESS-M technique offers comparable surgical outcomes to CLS-M, with advantages of shorter hospital stay and less pain after operation.