Endometriosis （EM） is a common chronic disease among women of childbearing age. It is characterized by the invasion of active endometrial tissue into tissues and organs outside the uterine cavity，often leading to dysmenorrhea，abnormal menstruation，infertility，dyspareunia，and a decrease in the quality of life. Although traditional laparoscopic surgery is the gold standard for treatment，its multi-port operation may be accompanied by an increase in incision complications and cosmetic problems. With the continuous development of minimally invasive technology，laparoendoscopic single-site surgery （LESS） can be completed through a single access route，showing the advantages of both minimal invasiveness and cosmesis. In recent years，LESS has received much attention in the treatment of EM. This article reviews the current application status，technical advantages，and existing challenges of LESS in the diagnosis and treatment of endometriosis，aiming to provide a reference for clinical practice.