Objective To explore the clinical effect of applying estradiol gel after repeated induced abortion. Methods A total of 127 women who underwent induced abortion in Jiangnan University Affiliated Maternal and Child Health Hospital（Wuxi Maternal and Child Health Hospital）from January 2023 to December 2023 were retrospectively analyzed，and they were divided into basic treatment group，estradiol gel group and contraceptive group according to postoperative treatment methods，with 45 cases，40 cases and 42 cases in each group.The average number of induced abortion in the 3 groups was ≥2 times，and all groups received induced abortion with negative pressure suction. The basic treatment group was given oral administration of Leonurus and cefdinir for 1 week. On this basis，the estradiol gel group was given percutaneous application of estradiol gel for 28 days starting from the day receiving surgery （it was stopped during menstrual period），and the contraceptive group was given oral administration of drospirosterone ethinylestradiol tablets （Ⅱ） for 28 days starting from the day receiving surgery. The endometrial thickness，duration of postoperative vaginal bleeding，recovery time of first menstruation，liver and kidney function，complications and adverse reactions were compared among the three groups after 7 and 21 days of treatment. Results The endometrial thickness of estradiol gel group was higher than that of contraceptive group and basic treatment group at 7 and 21 days after treatment，and the difference was statistically significant （P< 0.05）. The duration of postoperative vaginal bleeding in estradiol gel group was shorter than that in contraceptive group and basic treatment control group，and the incidence of uterine effusion and decreased menstrual volume was lower （P< 0.05）. The recovery time of first menstruation in the contraceptive group was shorter than that in the estradiol gel group and the basic treatment group （P < 0.05）. There was no difference between the time of menstruation after recovery and the pre-operative menstruation cycle in the estradiol group，and the time of menstruation after recovery in the basic treatment group was prolonged. There were no significant differences in the incidence of uterine cavity residue or liver and kidney function among the three groups（P>0.05）. Conclusion The effect of percutaneous estradiol gel on endometrial recovery after induced abortion is better than that of oral drospiroone ethoestradiol tablets and natural recovery，with good prognosis and fewer drug complications and adverse reactions.