Luteal phase defects（LPD）often contribute to advanced menstruation，hypomenorrhea，infertility and threatened abortion. The etiology and pathogenesis of LPD in TCM are mainly kidney deficiency，spleen and kidney deficiency or hepatic stagnation and kidney deficiency. The treatment is strengthening kidney and spleen，supplemented by soothing the liver and nourishing the blood. The research of our team suggests that Chinese herbal medicine prescription（CHMP）for strengthening kidney and spleen can increase the expression of progesterone receptor（PR）in endometrium or decidua and improve luteal effect. It has curative effect in regulating the menstrual function，preventing miscarriage and improving reproduction. Recently，a number of clinical and experimental studies have also found that the Chinese herbal compound for strengthening kidney and spleen and nourishing blood can effectively increase the number of ovarian antral follicles and improve ovarian reserve and function.