Abstract: Luteinized unruptured follicle syndrome（LUFS），one of the causes of female infertility，is a special phenotype of menstruation without ovulation. The mechanism of LUFS is still unclear. The possible high-risk factors include abnormal expression of hormone or local factors in ovaries that regulate the ovary cycle，mechanical factors in the pelvic cavity，as well as patient's psychological factors. Currently，no special treatment is recommended for the prevention of LUFS. High-risk factors can be dealt with to prevent LUFS，for example，high dose of hCG can be used to induce ovulation when dominant follicle is matured in patients with repeated LUFS. If LUFS occurs in natural cycle for frozen/thawed embryo transfer，luteal phase support should be strengthened or the cycle can be cancelled.

Key words: luteinized unruptured follicle syndrome, high-risk factors, clinical treatment

摘要： 未破裂卵泡黄素化综合征（luteinized unruptured follicle syndrome，LUFS）是无排卵性月经的一种特殊表型，也是导致不孕的原因之一。LUFS的发生机制尚不明确，可能的高危因素包括调控卵巢周期的激素水平或卵巢局部因子表达异常、盆腔局部机械因素以及患者的精神心理因素等。目前临床一般不对LUFS进行特殊处理，但可针对高危因素预防LUFS的发生，例如在卵泡发育的适当时机使用高剂量的人绒毛膜促性腺激素（human chorionic gonadotropin，hCG）诱发排卵；在自然周期进行冻胚移植中，若出现LUFS，可加强黄体支持。

关键词: 未破裂卵泡黄素化综合征, 高危因素, 临床处理