Luteinized unruptured follicle syndrome（LUFS），one of the causes of female infertility，is a special phenotype of menstruation without ovulation. The mechanism of LUFS is still unclear. The possible high-risk factors include abnormal expression of hormone or local factors in ovaries that regulate the ovary cycle，mechanical factors in the pelvic cavity，as well as patient's psychological factors. Currently，no special treatment is recommended for the prevention of LUFS. High-risk factors can be dealt with to prevent LUFS，for example，high dose of hCG can be used to induce ovulation when dominant follicle is matured in patients with repeated LUFS. If LUFS occurs in natural cycle for frozen/thawed embryo transfer，luteal phase support should be strengthened or the cycle can be cancelled.