Cervical high-grade squamous intraepithelial lesions belong to preinvasive lesions，most of which are caused by high-risk HPV persistent infection.Cervical conization is the mainstream treatment nowadays.The region to be excised must be set strictly according to the guideline.Individual strategy should be adopted to manage those with postoperative positive margin.Management of young woman and pregnancy with HSIL should be conservative when invasive lesion is excluded.Long-term follow-up is recommended as the risk of invasive cervical cancer among these women is about five times greater than that among the general population of women.