Embryo implantation is an important research direction of reproductive medicine.A successful embryo implantation，coordinating the implant-competency blastocyst with receptive uterus，determines pregnancy outcome and health condition of the newborn.By combining the implantation-related study in both mice and human，we summarizes the basic and clinical research progress in recent years in order to provide reference and guidance for improving pregnancy rate in assisted reproductive technology practice and reducing early pregnancy abortion rate.