Placental site trophoblastic tumor is a rare form of gestational trophoblastic disease.The most common clinical manifestations are amenorrhea and abnormal vaginal bleeding. The diagnosis must be based on pathological evidence.Immunohistochemistry plays an important role in the diagnosis and differential diagnosis of PSTT.PSTT is less chemosensitive than other forms of gestational trophoblastic neoplasm，thus operation is the primary treatment in most cases.Multiple agent chemotherapy combined with operation are recommended in patients with poor prognostic factors.Fertility-preserving treatment can be considered in highly-selected cases.