中国实用妇科与产科杂志

中国实用妇科与产科杂志

• 专题笔谈 • 上一篇    下一篇

常用宫缩抑制药物对胎儿的影响

  

  1. 山东省妇幼保健院妇产科 山东大学附属省立医院妇产科 国家卫计委生育调控技术重点实验室，山东 济南 250014
  • 出版日期:2017-11-02 发布日期:2017-11-03
  • 通讯作者: 王谢桐
  • 基金资助:

    泰山学者工程专项经费资助；国家自然科学基金（81571461）

Effect of commonly-used tocolytic drugs on fetuses

  1. Department of Obstetrics and Gynecology，Shandong Maternal and Child Health Hospital，Jinan 250014，China
  • Online:2017-11-02 Published:2017-11-03

摘要：

多数宫缩抑制药物并非专门用于抑制自发性早产。各种宫缩抑制药物对母体多种器官都有一定的副反应，但对于胎儿一般是安全的。β2-肾上腺素受体激动剂、缩宫素受体拮抗剂和钙通道阻滞剂对于胎儿相对安全；硫酸镁对早期早产儿的神经保护作用已经得到肯定，长期大量硫酸镁宫内暴露，可能导致胎儿及新生儿骨质减少和骨折；妊娠晚期应用前列腺素合成酶抑制剂对胎儿和新生儿有潜在的副反应，妊娠中期相对安全；阴道应用孕酮对胎儿影响轻微。

关键词: 自发性早产, 宫缩抑制药物

Abstract:

Most of tocolytic drugs currently in use are not developed specifically to treat preterm labour and have multi-organ side effects.β2-epinephrine agonists，oxytocin receptor blockers and calcium channel blockers are relatively safe for the fetus.The neuroprotective magnesium sulfate on the early preterm children has been affirmed，long-term and large amount of magnesium sulfate for intrauterine exposure may lead to fetal and neonatal bone loss and fracture.Prostaglandin synthetase inhibitors have potentially serious side effects on the fetus and neonate in the third trimester，but are safe in the second trimester.Vaginal progesterone is an effective tocolytic drug with minimal effect on the fetus.

Key words: spontaneous preterm labour, tocolytic drugs

中图分类号: