中国实用妇科与产科杂志

中国实用妇科与产科杂志

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宫颈鳞癌卵巢悬吊术后辅助放化疗对卵巢功能影响研究

丁迪楠，王敏，陶陶，王欣彦   

  1. 作者单位：中国医科大学附属盛京医院妇产科，辽宁 沈阳110004
  • 出版日期:2015-06-02 发布日期:2015-07-05
  • 通讯作者: 王敏

Effects of adjuvant therapy on ovarian function of patients with cervical squamous carcinoma after ovarian suspension.

DING Di-nan, WANG Min，TAO Tao，WANG Xin-yan.   

  1. Shengjing Hospital of China Medical University，Shenyang 110004，China
  • Online:2015-06-02 Published:2015-07-05

摘要：

目的 探讨宫颈鳞癌患者行卵巢悬吊术后辅助放化疗对卵巢功能的影响。方法 收集2008-2014年中国医科大学附属盛京医院收治的308例ⅠA~ⅡA期宫颈鳞癌行广泛性子宫切除术+盆（腹）腔淋巴清扫术+卵巢悬吊术的患者资料，按年龄（≥40岁和＜40岁）、悬吊卵巢的数量（单侧和双侧）、术后是否辅助治疗（辅助化疗、辅助放疗、辅助放化疗）分组。随访患者术后6个月情况，采用改良的围绝经期综合征量表（改良Kupperman评分表）评分，观察其卵巢功能受损症状出现情况。结果 按年龄、悬吊卵巢的数量分组之间改良Kupperman评分比较差异均无统计意义（P>0.05）。手术+放疗组、手术+放化疗组分别与手术组间改良Kupperman评分比较、手术+放疗组与手术+化疗组间改良Kupperman评分比较，差异均有统计学意义（P<0.05）。手术+化疗组与手术组，手术+化疗组与手术+放化疗组，手术+放疗组与手术+放化疗组之间改良Kupperman评分比较差异均无统计学意义（P>0.05）。结论 宫颈鳞癌行卵巢悬吊术患者术后辅助放疗或放化疗易影响卵巢的内分泌功能。年龄、悬吊卵巢的数量及术后辅助化疗与卵巢功能是否受损可能无关。

关键词: 宫颈癌, 卵巢悬吊术, 卵巢功能, 辅助治疗

Abstract:

Abstract： Objective To investigate the ovarian function of the patients receiving postoperative radiotherapy or chemotherapy after ovarian suspension in cervical squamous carcinoma.Methods Collect 308 cases of cervical squamous cell carcinoma in stage ⅠA~ⅡA patients who underwent radical hysterectomy and pelvic lymph node dissection and ovarian suspension surgery. Divide them into different groups according to the age, the quantity of ovarian suspension (unilateral and bilateral) or whether receiving postoperative adjuvant therapy (chemotherapy，adjuvant radiotherapy, chemotherapy+adjuvant radiotherapy) or not. The modified Kupperman Index was used to investigate the ovarian function of the patients in the following six months after the operation. Results According to the difference of the quantity of ovarian suspension or the age, modified Kupperman score had no statistical significance (P>0.05). Comparing the Group operation + radiotherapy with Group operation,Group operation + radiotherapy + chemotherapy with Group operation, Group operation + radiotherapy with Group operation + chemotherapy ,all the modified Kupperman scores had statistically significant (P<0.05). Comparing the Group operation + chemotherapy with Group operation, Group operation + chemotherapy with Group operation + radiotherapy + chemotherapy,Group operation + radiotherapy with Group operation + radiotherapy + chemotherapy,all the modified Kupperman scores showed no significant difference (P>0.05).Conclusions Postoperative radiotherapy or chemotherapy may affect the endocrine function of ovaries in patients receiving ovarian suspension.The ovarian function may have nothing to do with the age or the quantity of the ovaries.

Key words: cervical cancer, ovarian suspension, ovarian function, adjuvant therapy

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