组织工程补片及3D打印技术在盆腔重建手术中的应用前景

doi:10.7504/fk2015030104

中国实用妇科与产科杂志

组织工程补片及3D打印技术在盆腔重建手术中的应用前景

孙秀丽，常悦，王建六

作者单位：北京大学人民医院妇科，北京 100044

出版日期:2015-04-02 发布日期:2015-04-02
通讯作者: 王建六

The application prospect of tissue-engineered mesh with 3D printing technique in the pelvic floor reconstructive surgery.

SUN Xiu-li，CHANG Yue，WANG Jian-liu.

Peking University People’s Hospital,Beijng 100044,China

Online:2015-04-02 Published:2015-04-02

摘要/Abstract

摘要：

手术是重度盆腔器官脱垂主要的治疗方式。目前补片是盆底手术的焦点，聚丙烯补片虽能明显减低复发率，但有侵蚀、暴露、感染等副反应，生物源性补片虽有很好的组织相容性，但支持能力不强。目前，应用组织工程学及3D打印技术开发研制新型补片是研究热点。文章综述了目前国内外组织工程补片的研究现状及应用前景。

关键词: 盆底器官脱垂, 补片, 组织工程学, 3D打印

Abstract:

Abstract:Mesh surgery is the main therapy method for pelvic organ prolapse(POP).Synthetic mesh has the advantage of low recurrence rate but has the risk of erosion, exposure and infection.Biological mesh has better histocompatibility but is not strong enough. Tissue-engineered mesh with 3D printing technique is the key research point currently. Here we overview the studies and application prospect of tissue-engineered mesh.

Key words: pelvic organ prolapse;mesh;tissue-engineering, 3D printing technique

中图分类号:

R711.5

孙秀丽，常悦，王建六. 组织工程补片及3D打印技术在盆腔重建手术中的应用前景[J]. 中国实用妇科与产科杂志, DOI: 10.7504/fk2015030104.

SUN Xiu-li，CHANG Yue，WANG Jian-liu.. The application prospect of tissue-engineered mesh with 3D printing technique in the pelvic floor reconstructive surgery.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2015030104.

参考文献

［1］   Subak LL,Waetjen LE,Van den Eaden S,et al.Cost of pelvic organ prolapsed surgery in the United States［J］.Obstet Gynecol，2001,98:646-651.

［2］   Cassar K,Munro A. Surgical treatment of incisional hernia［J］.Br J Surg，2002,89:534-538.

［3］   Sun X, Zhang X, Wang J.Surgical outcomes and quality of life post-synthetic mesh-augmented repair for pelvic organ prolapse in the Chinese population［J］. J Obstet Gynaecol Res， 2014,40:509-514.

［4］   Griffis K, Hale DS. Grafts in pelvic reconstructive surgery［J］. Clin Obstet Gynecol， 2005,48: 713-723.

［5］   Trabuco EC, Klingele CJ, Gebhart JB. Xenograft use in reconstructive pelvic surgery: a review of the literature［J］. Int Urogynecol J Pelvic Floor Dysfunct， 2007, 18: 555-563.

［6］   Chaliha C, Khalid U, Campagna L, et al. SIS graft for anterior vaginal wall prolapse repair-a case-controlled study［J］. Int Urogynecol J Pelvic Floor Dysfunct, 2006, 17: 492-497.

［7］   Orabi H, Bouhout S, Morissette，et al. A tissue engineering of urinary bladder and urethra:advances from bench to patients［J］. Sci World J，2013, 24:1545-1564.

［8］   Mitterberger M, Pinggera GM, Marksteiner R, et al. Adult stem cell therapy of female stress urinary incontinence［J］. Eur Urol, 2008,53 : 169-176.

［9］   De Filippo R, Bishop C, Filho L, et al.Tissue engineering a complete vaginal replacement from a small biopsy of autologous tissue［J］. Transplantation，2008, 86: 208-214.

［10］   Xie Bing, Sun Xiuli, Wang Jianliu, et al. Three-dimensional modeling of the pelvic floor support systems of subjects with and without pelvic organ prolapse［J］. Biomed Res Int，2015(In press).

［11］   Sachs E, Cima M, Williams P, et al. Three dimensional printing: rapid tooling and prototypes directly from a CAD model［J］. J Engineering Industry, 1992，114:481-488.

［12］   Vacanti JP. Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation［J］.Lancet，1999，354(suppl):32.

［13］   Shishkovsky I. Synthesis of functional gradient parts via RP methods［J］. Rapid Prototyping J, 2001，7:207-212.

(2014-12-08收稿    2014-12-20修回）

组织工程补片及3D打印技术在盆腔重建手术中的应用前景

The application prospect of tissue-engineered mesh with 3D printing technique in the pelvic floor reconstructive surgery.

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐 0

Metrics