中国实用妇科与产科杂志

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卵巢癌干细胞及卵巢癌治疗

于风胜李艺崔恒   

  1. 作者单位:北京大学人民医院妇科肿瘤中心,北京100044
  • 出版日期:2014-01-02 发布日期:2014-01-02

Ovarian cancer stem cells and treatment of ovarian cancer. 

YU Feng-sheng,LI Yi,CUI Heng.   

  1. Peking University People's Hospital,Beijing 100044,China
  • Online:2014-01-02 Published:2014-01-02

摘要:

卵巢癌干细胞在卵巢癌发生、化疗耐药和复发过程中起重要作用。传统治疗对减小肿瘤体积有效,但是治疗后留下的卵巢癌干细胞成为卵巢癌复发和难治的根源。兼顾卵巢癌干细胞和普通肿瘤细胞的治疗策略才能真正有效治疗卵巢癌。对卵巢癌干细胞生物学特性和调控机制的了解是研究卵巢癌干细胞靶向治疗的基础。

关键词: 卵巢癌, 肿瘤干细胞

Abstract:

Abstract:Cancer stem cells or tumor-initiating cells (CSC/TICs) play critical roles in tumorigenesis, traditional therapy resistance, tumor recurrence and metastasis. Major causes of poor survival rates of ovarian cancer patients are tumor recurrence and chemoresistance due to the existence of CSC/TICs. Treatment targeting both CSC/TICs and bulk tumor cells is thought to be more effective to eliminate ovarian tumors. Better understanding of ovarian CSC/TICs might facilitate the development of improved therapeutic strategies for ovarian cancer.

Key words: ovarian cancer, cancer stem cells

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