

[1］ Flesken-Nikitin A, Hwang CI, Cheng CY, et al. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche ［J］. Nature, 2013,495(7440):241-245.

[2］ Bowen NJ, Walker LD, Matyunina LV, et al. Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells ［J］. BMC Medical Genomics, 2009, 71 (2)：121-126.

[3］ Jazedje T, Perin PM, Czeresnia CE, et al. Human fallopian tube:a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures ［J］. Journal of Translational Medicine, 2009, 46 (7)：801-807.

[4］ Hosonuma S, Kobayashi Y, Kojo S, et al. Clinical significance of side population in ovarian cancer cells ［J］. Human Cell, 2011,24(1):9-12.

[5］ Chau WK, Ip CK, Mak AS, et al. C-kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of wnt/beta-catenin-atp-binding cassette g2 signaling ［J］. Oncogene, 2013,32(22):2767-2781.

[6］ Cao L, Shao M, Schilder J, et al. Tissue transglutaminase links tgf-beta, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer ［J］. Oncogene, 2012,31(20):2521-2534.

[7］ Bignotti E, Tassi RA, Calza S, et al. Gene expression profile of ovarian serous papillary carcinomas:identification of metastasis-associated genes ［J］. American Journal of Obstetrics and Gynecology, 2007,196(3):245 e241-211.

[8］ Dressman HK, Muramoto GG, Chao NJ, et al. Gene expression signatures that predict radiation exposure in mice and humans ［J］. PLoS Medicine, 2007,4(4):e106.

[9］ Kurrey NK, Jalgaonkar SP, Joglekar AV, et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells ［J］. Stem cells, 2009,27(9):2059-2068.

[10］ Medema JP. Cancer stem cells:the challenges ahead ［J］. Nature Cell Biology, 2013,15(4):338-344.

[11］ Abubaker K, Latifi A, Luwor R, et al. Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden ［J］. Molecular Cancer, 2013,24(12):1601-1609.

[12］ Steg AD, Bevis KS, Katre AA, et al. Stem cell pathways contribute to clinical chemoresistance in ovarian cancer:clinical cancer research［J］.An Official Journal of the American Association for Cancer Research, 2012,18(3):869-881.

[13］ McAuliffe SM, Morgan SL, Wyant GA, et al. Targeting notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy ［J］. Proceedings of the National Academy of Sciences of the United States of America, 2012,109(43):E2939-2948.

[14］ Cheng W, Liu T, Wan X, et al. Microrna-199a targets cd44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells ［J］. The FEBS Journal, 2012,279(11):2047-2059.

[15］ Nam EJ, Lee M, Yim GW, et al. Microrna profiling of a cd133(+) spheroid-forming subpopulation of the ovcar3 human ovarian cancer cell line ［J］. BMC Medical Genomics, 2012, 18(5):601-603.

[16］ Zhang J, Guo X, Chang DY, et al. Cd133 expression associated with poor prognosis in ovarian cancer:modern pathology : an official journal of the［J］.United States and Canadian Academy of Pathology,2012,25(3):456-464.

[17］ Slomiany MG, Dai L, Tolliver LB, et al. Inhibition of functional hyaluronan-cd44 interactions in cd133-positive primary human ovarian carcinoma cells by small hyaluronan oligosaccharides:clinical cancer research［J］.An Official Journal of the American Association for Cancer Research, 2009,15(24):7593-7601.

[18］ Casagrande F, Cocco E, Bellone S, et al. Eradication of chemotherapy-resistant cd44+ human ovarian cancer stem cells in mice by intraperitoneal administration of clostridium perfringens enterotoxin ［J］. Cancer, 2011,117(24):5519-5528.

[19］ Yo YT, Lin YW, Wang YC, et al. Growth inhibition of ovarian tumor-initiating cells by niclosamide ［J］. Molecular Cancer Therapeutics, 2012,11(8):1703-1712.

[20］ Kumar S, Meuter A, Thapa P, et al. Metformin intake is associated with better survival in ovarian cancer: a case-control study ［J］. Cancer, 2013,119(3):555-562.

[21］ Yin G, Alvero AB, Craveiro V, et al. Constitutive proteasomal degradation of twist-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential ［J］. Oncogene, 2013,32(1):39-49.

[22］ Li Y, Zeng H, Xu RH, et al. Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer ［J］. Stem Cells, 2009,27(12):3103-3111.

[23］ Zhang Z, Chen X, Chang X, et al. Vaccination with embryonic stem cells generates effective antitumor immunity against ovarian cancer ［J］. International Journal of Molecular Medicine, 2013,31(1):147-153.

[24］ Dong W, Qiu C, Shen H, et al. Antitumor effect of embryonic stem cells in a non-small cell lung cancer model: Antitumor factors and immune responses ［J］. International Journal of Medical Sciences, 2013,10(10):1314-1320.