硫化氢与妊娠期并发症关系研究进展

刘丹综述,刘铭,段涛审校

中国实用妇科与产科杂志 ›› 2014, Vol. 30 ›› Issue (9) : 733-736.

中国实用妇科与产科杂志 ›› 2014, Vol. 30 ›› Issue (9) : 733-736. DOI: 10.7504/fk2014080123
综述

硫化氢与妊娠期并发症关系研究进展

  • 刘丹综述,刘铭,段涛审校
作者信息 +
文章历史 +

摘要

硫化氢(hydrogen sulfide,H2S)是一种有臭鸡蛋样气味的气体,长期以来,一直被视为是一种造成环境和职业性危害的有毒废气,有关硫化氢的毒理作用被广泛大量报道。长时间暴露于低浓度的硫化氢与支气管炎、肺炎等疾病发病相关,且硫化氢能够抑制线粒体的呼吸功能。直到1996年,Abe等发现生理剂量的H2S可以选择性地强化N-甲基-D-天(门)冬氨酸受体的功能,进而海马长时程增强,从此开启了研究H2S生理功能的大门。内源性H2S成为继一氧化碳(CO)及一氧化氮(NO)后的第3种气体信号分子。近年来研究发现,H2S在女性分娩期疾病的病理生理过程中发挥着重要作用。本文对H2S的生成、代谢及其对妊娠期并发症的病理生理调节作用等综述如下。
 

关键词

内源性硫化氢 / 早产 / 妊娠期高血压疾病 / 胎儿生长受限

Key words

endogenous hydrogen sulfide / preterm labor / hypertensive disorder complicating pregnancy

引用本文

导出引用
刘丹综述,刘铭,段涛审校. 硫化氢与妊娠期并发症关系研究进展[J]. 中国实用妇科与产科杂志. 2014, 30(9): 733-736 https://doi.org/10.7504/fk2014080123
中图分类号: R714.25   

参考文献

[1] Abe K,Kimura H.The possible role of hydrogen sulfide as an endogenous neuromodulator[J].J Neurosci, 1996, 16(3): 1066-1071.

[2] Zhao WM,Zhang J,Lu YJ,et al.The vasorelaxant effect of H2S as a novel endogenous gaseous K-ATP channel opener[J].Embo J, 2001, 20(21): 6008-6016.

[3] Yang G,Sun X,Wang R.Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3[J].FASEB J, 2004, 18(14): 1782-1784.

[4] Patel P,Vatish M,Heptinstall J,et al.The endogenous production of hydrogen sulphide in intrauterine tissues[J].Reprod Biol Endocrinol, 2009, 7(10):doi: 10.1186/1477-7827-7-10.

[5] American College of Obstetricians and Gynecologists.ACOG Practice Bulletin. Assessment of risk factors for preterm birth. Clinical management guidelines for obstetrician-gynecologists. Number 31, October 2001. (Replaces Technical Bulletin number 206, June 1995; Committee Opinion number 172, May 1996; Committee Opinion number 187, September 1997; Committee Opinion number 198, February 1998; and Committee Opinion number 251, January 2001)[J].Obstet Gynecol, 2001, 98(4): 709-716.

[6] Zhang L,Sio SWS,Moochhala S,et al.Role of hydrogen sulfide in severe burn injury-induced inflammation in mice[J].Mol Med, 2010, 16(9-10): 417-424.

[7] Fiorucci S,Orlandi S,Mencarelli A,et al.Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis[J].Brit J Pharmacol, 2007, 150(8): 996-1002.

[8] Li L,Bhatia M,Zhu YZ,et al.Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse[J]. FASEB J, 2005, 19(6): 1196-1205.

[9] Sidhu R,Singh M,Samir G,et al.L-cysteine and sodium hydrosulphide inhibit spontaneous contractility in isolated pregnant rat uterine strips in vitro[J].Pharmacol Toxicol, 2001, 88(4): 198-203.

[10] You XJ,Xu C,Lu JQ,et al.Expression of cystathionine β-synthase and cystathionine gamma-lyase in human pregnant myometrium and their roles in the control of uterine contractility[J].Plos One, 2011, 6(8): doi: 10.1371/journal.pone.0023788.

[11] Zhao P,Huang X,Wang ZY,et al.Dual effect of exogenous hydrogen sulfide on the spontaneous contraction of gastric smooth muscle in guinea-pig[J].Eur J Pharmacol, 2009, 616(1-3): 223-228.

[12]  Hosoki R,Matsuki N,Kimura H.The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide[J].Biochem Bioph Res Co, 1997, 237(3): 527-531.

[13] Li L,Whiteman M,Guan YY,et al.Characterization of a novel, water-soluble hydrogen sulfide - releasing molecule (GYY4137):unew insights into the biology of hydrogen sulfide[J].Circulation, 2008, 117(18): 2351-2360.

[14] Maynard SE,Min JY,Merchan J,et al.Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfimction, hypertension, and proteinuria in preeclampsia[J].J Clin Invest, 2003, 111(5): 649-658.

[15] Venkatesha S,Toporsian M,Lam C,et al.Soluble endoglin contributes to the pathogenesis of preeclampsia (vol 12, pg 642, 2006)[J].Nat Med, 2006, 12(7): 862-873.

[16] Wang KQ,Ahmad S,Cai M,et al.Dysregulation of hydrogen sulfide producing enzyme cystathionine gamma-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia[J].Circulation, 2013, 127(25): 2514-2522.

[17]    Li L,Hsu A,Moore PK.Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation - a tale of three gases![J].Pharmacol Therapeut, 2009, 123(3): 386-400.

[18] Cindrova-Davies T,Herrera EA,Niu YG,et al.Reduced cystathionine gamma-lyase and increased mir-21 expression are associated with increased vascular resistance in growth-restricted pregnancies hydrogen sulfide as a placental vasodilator[J].Am J Pathol, 2013, 182(4): 1448-1458.

[19] Xu S, Liu Z, Liu P.Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis[J].Int J Cardiol,2014,172(2):313-317.

(2014-02-01收稿    2014-05-29修回)


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