博洛尼亚标准&mdash;卵巢反应不良共识的解读

古芳; 徐艳文

doi:10.7504/fk2015070104

PDF(916 KB)

中国实用妇科与产科杂志 ›› 2015, Vol. 31 ›› Issue (8) : 699-702. DOI: 10.7504/fk2015070104

综述

博洛尼亚标准—卵巢反应不良共识的解读

古芳,徐艳文

作者信息 +

文章历史 +

摘要

2011年欧洲人类生殖与胚胎协会（European Society of Human Reproduction and Embryology,ESHRE）首次推出了卵巢反应不良（poor ovarian response，POR）的共识。自从该诊断标准的提出就引来了许多的讨论和争议。诚然，POR共识为今后该领域的研究规范了一个相对同质性的人群，从而使临床数据更准确和可靠。然而，其标准设定的准确性、诊断价值的高低以及纳入人群的均一性均有待进一步的研究和验证。因此，我们需要使用设计严谨的RCT对该标准细则进行验证，才可充分评估其临床应用价值。

导出引用

古芳,徐艳文. 博洛尼亚标准—卵巢反应不良共识的解读[J]. 中国实用妇科与产科杂志. 2015, 31(8): 699-702 https://doi.org/10.7504/fk2015070104

中图分类号： Ｒ321.33

参考文献

［1］ Ferraretti AP, La Marca A, Fauser BC,et al. ESHRE Working Group on Poor Ovarian Response Definition. ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria［J］. Hum Reprod,2011,26（7）:1616-1624.

［2］   武学清，孔蕊，田莉,等.卵巢低反应专家共识［J］.生殖与避孕,2015,35（2）：71-79.

［3］   Davar R, Oskouian H, Ahmadi S,et al. GnRH antagonist/letrozole versus mic rodose GnRH agonist flare protocol in poor responders undergoing in vitro fertilization［J］. Taiwan J Obstet Gynecol,2010,49（3）：297-301.

［4］   Polyzos NP, Devroey P. A systemic review of randomized trials for the treatment of poor ovarian responders: is there any light at the end of the tunnel? ［J］.Fertil Steril,2011,96(5):1058-1061.

［5］   Khalaf Y, El-Toukhy T, Taylor A,et al. Increasing the gonadotrophin dose in the course of an in vitro fertilization cycle does not rectify an initial poor response［J］. Eur J Obstet Gynecol Reprod Biol,2002,103 (2):146-149.

［6］   Mutlu MF, Erdem M, Erdem A,et al. Antral follicle count determines poor ovarian response better than anti-mullerian hormone but age is the only preditor for live birth in in vitro fertilization cycles［J］. J Assist Reprod Genet,2013,30(5):657-665.

［7］   Broer SL, van Disseldorp J, Broeze KA,et al. Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach［J］. Hum Reprod Update,2013,19(1):26-36.

［8］   Rosen MP, Johnstone E, McCuloch CE,et al. A characterization of the relationship of ovarian reserve markers with age［J］.Fertil Steril,2012, 97(1):238-243.

［9］   Bhattacharya S, Maheshwari A, Mollison J.Factors associated with failed treatment: an analysis of 121744 women embarking on their first IVF cycles［J］. PLoS One,2013,8(12):82249.

［10］   Polyzos NP, Nwoye M, Corona R,et al. Live birth rates in Bologna poor responders treated with ovarian stimulation for IVF/ICSI［J］. RBM Online, 2014,28(4):469-474.

［11］   Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: a committee opinion ［J］.Fertil Steril,2015,103 (3):9-17.

［12］    Nelson SM, La Marca A. The journey from the old to the new AMH assay: how to avoid getting lost in the values［J］. Reprod Biomed Online, 2011,23(4):411-420

［13］   Rustamov O, Smith A, Roberts SA, et al. Anti-Mullerian hormone: poor assay reproducibility in a large cohort of subjects suggests sample instability［J］. Hum Reprod,2012,27(10):3085-3091.

［14］Fleming R, Nelson SM. Reproducibility of AMH［J］. Hum Reprod,2012,27(12): 3639-3641.

［15］    Nelson SM. Biomarkers of ovarian response: current and future applications current and future applications［J］. Fertil Steril,2013,99 (4):963-969.

［16］   Broer SL, Mol BW, Hendriks D,et al. The role of anti-Mullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count［J］. Fertil Steril,2009,91(3):705-714.

［17］   La Marca A, Sighinolfi G, Radi D,et al. Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART) ［J］. Hum Reprod Update,2010,16(2):113-130.

［18］    La Marca A, Sunkara SK. Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice［J］. Hum Reprod Update,2014,20(1):124-140.

［19］    Younis JS. The Bologna criteria for poor ovarian response; has the job been accomplished［J］?.Hum Reprod,2012,27(6):1874-1875.

［20］   Papathanasiou A.Implementing the ESHRE 'poor responder' criteria in research studies: methodological implications［J］.Hum Reprod,2014,29 (9):1835-1838.

［21］   Klinkert ER, Broekmans FJ, Looman CW, et al. A poor ovarian response in the first cycle is not necessary related to a poor prognosis in subsequent cycles［J］. Fertil Steril,2004,81:1247-1253.

［22］   Ferraretti AP, Gianaroli L. The Bologna criteria for the definition of poor ovarian responders: is there a need for revision［J］?.Hum Reprod, 2014,29(9):1842-1845.

［23］   Venetis CA. The Bologna criteria for poor ovarian response: the good, the bad and the way forward［J］.Hum Reprod,2014,29(9):1839-1841.

（2015-04-10收稿 2015-05-18修回）