中国实用妇科与产科杂志

• 述评 • 上一篇    下一篇

从DOHaD理论看孕期营养干预的重要性

李婷段涛   

  1. 作者单位:同济大学附属第一妇婴保健院,上海 200040
  • 出版日期:2014-08-02 发布日期:2014-07-23

Importance of intervening the nutritional problems during pregnancy in based on evidences of developmental origins of health and disease (DOHaD).

LI Ting,DUAN Tao.   

  1. Shanghai First Maternity and Infant Hospital, Tongji University,Shanghai 200040, China
  • Online:2014-08-02 Published:2014-07-23

摘要:

孕期可能出现多种营养问题。与健康和疾病发育起源学说(DOHaD)的相关研究显示,妊娠期热量摄入过多或过少、三大营养素水平失衡以及包括铁、叶酸在内的多种微量营养素缺乏,都可以通过改变胎儿下丘脑-垂体-肾上腺素轴应答、氧化应激状态、表观遗传学等机制,永久的改变后代对疾病的易感性,增加成年期慢性疾病的发生。产科医生需根据循证医学证据,在孕期对所有孕妇实施合理的营养干预,提高整个人群的健康素质。

关键词: 健康和疾病的发育起源, 慢性成人疾病, 营养干预, 妊娠期

Abstract:

Abstract: Pregnancy women may facing various nutritional problems during pregnancy including excess or insufficient energy intake, imbalance of macronutrients, deficiency of micronutrient . Based on evidences of developmental origins of health and disease (DOHaD), the fetal hypothalamic - pituitary - adrenaline-axis response, oxidative stress and epigenetic mechanisms can be permanently changed by these nutritional problems. The susceptibility to chronic non-communicable disease in adulthood is changed. Obstetricians should intervene the nutritional problems based on uptodate evidences to improve the health of the whole population.

Key words: developmental origins of health and disease, chronic non-communicable diseases in adulthood, nutrition interventions, pregnancy

中图分类号: