中国实用儿科杂志

中国实用儿科杂志

• 专题笔谈 • 上一篇    下一篇

益生菌在儿童过敏性疾病的应用

  

  1. 深圳市儿童医院呼吸科，广东  深圳  518026
  • 出版日期:2017-02-06 发布日期:2017-02-06

Application of probiotics in children with allergic disease

  1. Department of Respiratory，Shenzhen Children’s Hospital，Shenzhen  518026，China
  • Online:2017-02-06 Published:2017-02-06

摘要：

过敏性疾病包括过敏性鼻炎、过敏性结膜炎、支气管哮喘、特应性皮炎、食物过敏等，已经被证实与肠道菌群的紊乱有关。过敏动物模型研究显示，益生菌能够通过诱导调节性T细胞产生，降低过敏原特异性IgE和Th2细胞因子分泌 ，减轻靶器官嗜酸性粒细胞浸润和过敏性炎性反应，从而改善过敏表现。益生菌在临床上应用于婴幼儿湿疹有比较确切的治疗效果，但是用于过敏性疾病的预防证据不一致，仅在过敏性疾病高危人群中推荐使用。

关键词: 益生菌, 过敏性疾病, 儿童

Abstract:

There is strong evidence implicating the intestinal flora disturbance in developing allergic disease including allergic rhinoconjunctivitis，asthma，eczema and food allergy. Experimental studies with animal model of allergy have shown that probiotics can improve allergic manifestations by induceing immune regulation Treg cell，inhibiting the secretion of allergen-induced IgE and Th2 cytokines，attenuating eosinophils infiltration and allergic inflammation in target organs. Probiotics have been proved effective in treatment of IgE-mediated eczema;however，because of the conflicting results，probiotics are recommended for prevention of allergy only in populations at high risk of allergy.

Key words: probiotics；allergic , disease；child