中国实用儿科杂志

中国实用儿科杂志 ›› 2011, Vol. 26 ›› Issue (12): 924-.

• 论著 • 上一篇    下一篇

住院患儿EB病毒感染血清流行病学调查分析

  

  1. 重庆医科大学附属儿童医院感染消化科，重庆　400016
  • 出版日期:2011-12-06 发布日期:2011-12-01

Seroepidemiological study of Epstein-Barr virus infection in hospitalized children.

  1. Infection and Digestive Department，Children’s Hospital Affiliated to Chongqing Medical University，Chongqing 400014,China
  • Online:2011-12-06 Published:2011-12-01

摘要：

摘要：目的　 了解住院患儿EB病毒（Epstein-Barr virus，EBV）的流行情况。方法　对2009 - 01 - 01—2009 - 12 - 31在重庆医科大学附属儿童医院临检中心应用酶联免疫吸附法（ELISA）行EBV衣壳抗原（EBVCA）血清学检查的结果进行全面调查，从性别、年龄及季节等方面统计EBV的感染情况。结果　18岁以下住院患儿EBV总体感染率为35.27%，新发感染率为12.66%。EBV的累积感染率随年龄增长逐渐增高，至学龄前期近半数儿童已发生感染，3～5岁为感染发生的高峰年龄。0～3个月、 > 3～6个月、 > 6～12个月、 > 1～2岁、 > 3～5岁、 > 6～12岁、 > 12～18岁的EBV累积感染率分别为27.70%（实际低于该值）、10.48%、14.13%、27.69%、44.61%、51.99%、57.34%；新发感染率分别为1.15%、1.25%、2.52%、12.55%、22.21%、18.55%、20.3%。3月及9～10月EBV的新发感染率较高，差异具有统计学意义（P < 0.05）。不同年龄阶段按性别比较EBV累积感染率及新发感染率除1～2岁组有差异外（P < 0.05），其余各组均无差异（P > 0.05）。结论　住院患儿EBV的感染率较国内的既往报道明显降低，学龄前儿童已有近半数发生感染，3～5岁为感染的高峰年龄段。 EBV的累积感染率及新发感染率无性别差异；3月及9～10月感染率较高。

关键词: 儿童 , EB病毒, 血清流行病学, 衣壳抗原

Abstract:

Abstract：Objective　To understand the prevalence of Epstein-Barr virus in hospitalized children. Methods　All results of anti-VCA-IgM and anti-VCA-IgG to Epstein-Barr virus detected by ELISA in Chongqing Children’s Hospital from January to December in 2009 were collected. The data was counted using statistical analysis of Chi-Square Test by gender， age group and season. Results　The total infection rate of Epstein-Barr virus for hoapitalized children under 18 years old was 35.27% in 2009 and the recent infection rate was 12.66%.The accumulation infection rate gradually increased with ages， and nearly half of children had been infected by Epstein-Barr virus in pre-school age group. The period from 3 to 5 years old was the peak age of infection. The accumulation rate among 0～3 months， 3～6 months， 6～12 months， 1～2 years， 3～5 years， 6～12 years and 13～18 years old was 27.70%， 10.48%， 14.13%， 27.69%， 44.61%， 51.99% and 57.34%， respectively. And the recent infection rate was 1.15%， 1.25%， 2.52%， 12.55%， 22.21%， 18.55% and 20.3%， respectively. The recent infection rates in March， September and October were higher than those of others in 2009， and the difference was statistically significant （P < 0.05）. Except the 1～2 years group （P < 0.05）， there was no difference in other age groups about the cumulative and the recent infection rate by gender （P > 0.05）. Conclusion　1. The infection rate of Epstein-Barr virus for childen is lower than that reported before in China. Nearly half of children have been infected by Epstein-Barr virus in pre-school age group， the peak period of infection being 3～5 years old.2. There is no gender difference of cumulative and recent infection rate in Chongqing in 2009， the infection rate in March and September-October were higher than those of others.

Key words: child, Epstein-Barr virus, seroepidemiology, capsid antigen