中国实用儿科杂志 ›› 2011, Vol. 26 ›› Issue (8): 600-.

• 论著 • 上一篇    下一篇

哮喘患儿变应原特异性免疫球蛋白E与总免疫球蛋白E相关性研究

  

  1. 首都儿科研究所,北京 100045
  • 收稿日期:2011-03-15 修回日期:2011-05-20 出版日期:2011-08-06 发布日期:2011-09-19

Relationship between total and specific IgE in patients with asthma

  1. Capital Pediatric Research Institute,Beijing 100045,China
  • Received:2011-03-15 Revised:2011-05-20 Online:2011-08-06 Published:2011-09-19

摘要:

目的 探讨哮喘患儿血清总免疫球蛋白E(IgE)及特异性免疫球蛋白E(SIgE)之间的关系,验证血清总IgE(TIgE)水平是否直接依赖于环境中占优势的变应原所诱导的SIgE(SIgE)升高而升高的观点。方法 收集2007年1月至2010年6月首都儿科研究所附属北京儿童医院门诊及住院的哮喘、咳嗽变异性哮喘(CVA)患儿219例,年龄3~16岁,平均(6.5±3.3)岁;其中男165例,女54例。应用荧光酶联免疫方法,进行混合真菌(mx1)、粉尘螨(d1)、户尘螨(d2 )、猫毛(e1 )、狗毛(e5 )、艾蒿(w6)血清SIgE抗体和TIgE的测定。 结果 219例患儿中SIgE阳性率分别是mx1 : 45.7 %、d1 : 32%、d2 : 31.5%、e1 : 25.1%、e5 : 18.7%、w6 : 21.5%,中重度患儿的SIgE(≥ 50 U/mL)阳性比率是mx1 : 14.16%、d1 : 12.79 %、d2 : 15.53%、e1 : 8.22%、e5 : 1.14%、w6 : 2.74%,(1)mx1、d1、d2、e1、e5、w6血清SIgE抗体对TIgE的升高有显著意义,均为(r = 0.000,P < 0.01)。(2)本值是以200为分界值,以TIgE ≥ 200 U/mL的病例为一组值进行分析,在TIgE ≥ 200 U/mL者中特异性e1及特异性e5 IgE抗体明显导致TIgE的升高(P < 0.01),而d2、d1、w6与高TIgE无相关性(P>0.01)。结论 环境中占优势的过敏原并不都是可以导致较高的TIgE水平。

关键词:  , 哮喘, 咳嗽变异性哮喘, 变应原, 血清免疫球蛋白E

Abstract:

Abstract : Objective To investigate the relationship between total immunoglobulin E (tIgE) and specific immunoglobulin E (sIgE) in serum,and verify whether the elevation of serum tIgE directly depends on increasing sIgE against the dominant allergen in the environment. Methods Totally 219 out-patients or in-patients with asthma or cough variant asthma(CVA) were selected randomly in our hospital from January 2007 to June 2010. There were165 male and 54 female patients,with age ranging from 3 to 16 (mean : 6.5). With blood samples,tIgE and sIgE directly against mixed molds (mx1),dermatophagoides pternonyssinus (d1),dermatophagoides farinae (d2),cat (e1),dog (e5),and artemisia vulgaris (w6) respectively were assayed by fluoroenzyme-immunometric assay,UniCAP100. Results We observed that in 219 patients,sIgE positive rates were 45.7% for mx1,32% for d1,31.5% for d2,25.1% for e1,18.7% for e5 and 21.5% for w6,respectively. ① The elevation of tIgE was highly related to sIgE directly against mx1,d1,d2,e1,e5 and w6 respectively (t = 0.000,P < 0.01). ② When tIgE was more than 200 U/mL,we observed that sIgE could lead to tIgE increasing significantly in c1 an e5 group (P < 0.01),but not in d2,d2 and w6 (P > 0.01). Conclusion It is not a universal phenomenon that the dominant allergen in the environment could lead to tIgE increasing strongly.

Key words: asthma, cough variant asthma, aeroallergens, serum IgE