关键词: 川崎病, 降钙素原, 白介素6, 并发症

Abstract: AbstractObjectiveTo study the changes of serum PCT and IL-6 levels in Kawasaki disease (KD) patients, and evaluate the relationships of them with complications. MethodsTotally 88 KD patients and 33 healthy children were recruited in this study. KD patients were divided into different groups. Serum PCT and IL-6 concentrations of KD patients were compared with healthy children, and compared within different groups. Results(1) Serum PCT concentrations of acute patients were significantly higher than subacute patients and healthy children ,0.55(0.30～1.81)ng/ml vs. 0.49(0.20～0.50)ng/ml(P<0.05) and 0.55(0.30～1.81)ng/ml vs. 0.16(0.14～0.24)ng/ml(P<0.01). (2) Serum concentrations of PCT were significantly higher in acute patients with noncardiac complication as compared to those without noncardiac complication, 1.67(0.49～4.14) ng/ml vs. 0.47(0.27～0.74) ng/ml (P<0.01). Noncardiac complications occurred in 16.3%(8/41) acute patients if PCT levels were ≤0.5ng/mL, and the incidence increased to 41.0% (16/23) if PCT levels were > 0.5ng/mL, χ2 = 6. 68( P<0.05). (3) Serum IL-6 concentrations of acute patients were significantly higher than subacute patients and healthy children, 43.34（13.67～132.72）pg/ml vs. 8.62（7.56～56.54）pg/ml(P<0.01) , and 43.34（13.67～ 132.72）pg/ml vs. 8.80（6.00～13.05）pg/ml(P<0.01). (4) Significantly higher serum IL-6 concentrations were shown in acute patients with noncardiac complication than those without noncardiac complication, 110.97(21.00～148.79) pg/ml vs. 26.13(9.34 ～78.84) pg/ml, P<0.01. Conclusion(1) There is significant elevation of serum PCT and IL-6 concentrations in all KD patients,and the concentrations of them gradually decreased with the development of KD. High levels of PCT can last longer than those of IL-6. (2) Significantly high serum PCT and IL-6 concentrations were observed in KD patients with noncardiac complications,and it may be a useful index for evaluating KD patients.

Key words: Complication , Procalcitonin, Interleukin-6