关键词: Tourette综合征, 抗链球菌溶血素O, 细胞免疫功能, 免疫治疗

Abstract: AbstractObjectiveTo observe the changes of serum antistreptolycin O(ASO),Tlymphocyte subgroups and natural killer cell(NKC)，and to explore the immune functional state and effect of immunomodulator in children with Tourette s syndrome(TS). MethodsASO and the proportion of T lymphocyte subgroups,NKC in serum were measured in 58 cases of TS using turbidimetry and Bicolor immunofluorescence,respectively.Those of the healthy children were also measured as controls during the same period of time.Those TS children whose immune functions were abnormal were divided randomly into two groups and were treated respectively by using simple immunomodulator Pidotimod Granules and by using dopaminergic receptor antagonists while using Pidotimod Granules. ResultsThe positive rate of ASO in TS children was markedly higher than those of healthy children(P<0.05);the level of CD+4 in children with TS whose ASO was positive was markedly lower than that of those whose ASO was negative(P<0.05);the levels of CD+3,CD+4,CD+4 /CD8+ in children with TS were significantly depressed as compared to those in control(P<0.05).The level of NKC in TS was significantly increased as compared to that in healthy control group(P<0.05).Among the TS children whose immune functions were abnormal,there was no significant difference in the therapeutic effect between the two groups treated respectively by using simple immunomodulator and by using dopaminergic receptor antagonists while using immunomodulator. ConclusionGroup A streptococcal infection might be associated with TS;streptococcal infection may be responding in the change of the cellular immunity,which shows that CD+4 is at low level and the disequilibrium of T lymphocyte subgroups and NKC is at high level.Immunotherapy may be effective in treating TS triggered by streptococcal infections.

Key words: Treatment of immunomodulator , Antistreptolycin O, Cellular immune function