中国实用儿科杂志

中国实用儿科杂志

• 论著 • 上一篇    下一篇

原发性肾病综合征患儿血脂代谢紊乱的肾毒性作用

胡鹏，经承学，覃远汉，裴娟，李铭芳   

  1. 广西医科大学第一附属医院儿科，广西南宁530021
  • 收稿日期:2006-05-07 修回日期:2006-10-10 出版日期:2007-02-06 发布日期:2007-02-06
  • 通讯作者: 经承学

Nephrotoxicity induced by dyslipidemia in children with primary nephritic syndrome.

HU Peng,JING Chengxue,QIN Yuanhan,et al.   

  1. Department of Pediatrics,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China
  • Received:2006-05-07 Revised:2006-10-10 Online:2007-02-06 Published:2007-02-06

摘要： 目的探讨原发性肾病综合征患儿(PNS)血脂代谢紊乱与肾功能改变的关系。 方法200401—200601，根据肾功能检查结果，将广西医科大学第一附属医院儿科收治的76例PNS患儿分成无肾功能损害组(46例)与肾功能损害组(30例)，检测血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、非高密度脂蛋白(nonHDL)、低密度脂蛋白(LDL)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、ApoA1/B、血浆尿素氮(BUN)、肌酐清除率(Ccr)和尿酸(UA)等指标。 结果(1)肾功能损害组TG、BUN、Ccr和UA均明显高于无肾功能损害组；(2)76例PNS患儿TG与Ccr及UA呈高度正相关(P<0.01)，ApoA1与Ccr呈中度正相关(P<0.05)，ApoB与UA呈中度正相关(P<0.05)；(3)76例PNS患儿nonHDL与LDL呈高度正相关(P<0.01)。 结论PNS合并肾功能损害的血脂代谢紊乱以TG显著增高为特征；TG和nonHDL变化可以作为临床判断PNS患儿肾功能损害程度及调脂措施有效性的指标。

关键词: 肾病综合征, 高脂血症, 肾功能, 儿童

Abstract: AbstractObjectiveTo probe into the relationship between dyslipidemia and the alternation of renal function in children with primary nephritic syndrome(PNS). MethodsTotally 76 children with PNS were divided into two groups,the nonrenal inadequacy group(46 children) and the renal inadequacy group(30 children),according to renal function.Total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),nonHDL,low density lipoprotein(LDL),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),ApoA1/B,blood urea nitrogen(BUN),creatinine clearance rate(Ccr) and uric acid(UA) in plasma were detected. Results(1) TG,BUN,Ccr and UA in the renal inadequacy group significantly increased compared with the nonrenal inadequacy group.(2) There was outstanding positive correlation between TG and Ccr,UA(P<0.01),medium positive correlation between ApoA1 and Ccr(P<0.05),medium positive correlation between ApoB and UA(P<0.05)in 76 PNS children.(3) Outstanding positive correlation was observed between nonHDL and TG(P<0.01)in 76 PNS children. ConclusionSignificantly increased TG is the feature of dyslipidemia in PNS children complicating renal inadequacy.It is favorable identification for TG,nonHDL to judge the degree of renal inadequacy and the efficacy of therapy in clinic.

Key words: Children , Hyperlipidemia, Renal function