中国实用儿科杂志

中国实用儿科杂志

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尿微量蛋白和尿酶在儿童过敏性紫癜早期肾损伤中的临床意义

陈华a，张亚京a，王鑫a，要利明b，郝景丽a，任静a，黄学英a，张玲玲a   

  1. 内蒙古医学院第三附属医院 a儿科 b检验科，内蒙古包头014010
  • 收稿日期:2006-07-11 修回日期:2006-10-06 出版日期:2007-02-06 发布日期:2007-02-06

Clinical research into renal early injury indexes in children with HenochSchonlein purpura.

CHEN Hua,ZHANG Yajing,WANG Xin,et al.   

  1. Department of pediatrics Inner Mongolia Medical College Third Affiliated Hospital,Baotou 014010，China
  • Received:2006-07-11 Revised:2006-10-06 Online:2007-02-06 Published:2007-02-06

摘要： 目的探讨尿微量蛋白和尿酶在过敏性紫癜(HSP)患儿早期肾损伤中的作用和临床意义。 方法200410—200510在内蒙古医学院第三附属医院儿科和皮肤科住院的HSP患儿共43例，采用免疫散射比浊法和酶法测定患儿尿微量白蛋白(MA)、转铁蛋白(TRF)、β2微球蛋白(β2MG)和尿酶N乙酰βD氨基葡萄糖胺酶(NAG)的水平，同时检测尿常规和血尿素氮(BUN)、肌酐(Scr)水平。 结果HSP患儿尿4项指标明显高于对照组，4项指标异常率79.07%(34/43)，尿常规异常率13.95%(6/43)；37例尿常规正常者4项指标异常率达70.57%(28/37)，且4项指标较单项指标异常发生率高。 结论尿4项指标联合检测是诊断HSP早期肾损伤的灵敏指标，可作为临床早期诊断、早期干预治疗以降低肾损伤程度的可靠依据。

关键词: 紫癜, 过敏性, 早期肾损伤, 尿微量蛋白, N乙酰βD氨基葡萄糖胺酶, 儿童

Abstract: AbstractObjectiveTo investigate the action and clinical significance of urine microprotein and NAG as indexes of renal early injury,in children with HenochSchonlein purpura(HSP). MethodsWe measured urine micro protein and enzyme by immune scatter turbidimetry and enzymatic assay,and at the same time did urine routine analysis,examined blood urea nitrogen(BUN )and serum creatinine(Scr) in the 43 cases of HSP. ResultsIn 43 cases group the four indexes were obviously higher than control group,abnormal rate of urine routine analysis being 13.95%,abnormal rate of the four indexes 79.07%; 37cases of normal urine routine analysis had abnormal four indexes,being 70.57%,and abnormal rate of the four index were higher than that of the single index. ConclusionCombined four indexes in urine is a sensitive index to find renal early injury in HSP,and could be credibility index in early diagnosis,treatment and in achieving favorable prognosis.

Key words: NaletyleβDglu cosaminedase, Children , Renal early injury, Urine microprotein