关键词: 肾病综合征, 高脂血症, 降脂药, 诺衡

Abstract: AbstractObjectiveIt was known that hyperlipidemia,as one complication of nephrotic syndrome,had renal toxicity.To observe the effect and security of gemfibrozil treating hyperlipidemia in children with active steroidresistance nephrotic syndrome(SR NS).MethodsEight children with SRNS were administered gemfibrozil (BWt<20kg,0.3/d; BWt>20kg,0.3 Bid) whit normal liver function before lipidlowing treatment.The changes of plasma lipids (TC,TG) and lipoprotins (LDL,VLDL,HDL),albumin,serum creatinine(SCr),aminotransferase(ALT) and drug sideeffects were observated for 4 weeks.ResultsWe found that there were decreasing of plasma lipids and lipoproteins after 2 weeks of gemfibrozil treatment,especially TG(P<0.05).The decreasing of TC,VLDL,LDL and raising of HDL had significant difference at 4th week.The average reducing rate of TG was 48.2%,TC was 31.8%.There were no significant difference between before and after lipidlowing treatment in renal and liver function.All of our patients' renal and liver function was in normal range except that one boy who had renal insufficiency before gemfibrozil treatment had little raising of Scr.There was no sideeffect found except another patient who had temporary abdominal pain and nausea.ConclusionOur result showed that it is effective and safe to treat the steroidresistence nephrotic hyperlipidemia in childhood with gemfibrozil for shortterm,especially for patients with raising TG,but we would pay more attention to patients with renal insufficiency.

Key words: Gemfibrozil , Hyperlipidemia, Lipidlowing treatment