关键词: 川崎病, 冠状动脉损伤, 危险因素

Abstract: AbstractObjectiveTo summarize the clinical pictures and laboratory study results of children with Kawasaki disease,and further analyze the risk factors of coronary complications in Kawasaki disease. MethodsAll charts of consecutive children with a diagnosis or suspicious diagnosis of Kawasaki disease from January 1,2000 to December 31,2004 were reviewed retrospectively.Children with clinical pictures satisfied to the 5th revision of diagnostic criteria of Kawasaki disease were included.Patients gender,age,duration of fever,use of intravenous gamma immunoglobublin (IVIG),corticosteriod use,laboratory study results,and echocardiographic study results were summarized.Chisquare test and logistic regression were performed to analyze the risk factors of coronary abnormalities. ResultsA total of 644 patients with Kawasaki disease were enrolled as the subjects of this study.Their age ranged from 1 month to 13.3 years of age,Laboratory study showed most of patients had elevation of ESR,Creactive protein,WBC count,platelet count,while some of them had hypoalbuminemia and anemia.Out of all patients,644 had coronary dilation with an incidence of 36.3%.Coronary aneurysm was identified in 16 patients with an incidence of 2.5%.Statistical analysis showed that gender,duration between onset and IVIG treatment,dosage of IVIG,duration of fever,ESR and CRP were related to coronary abnormalities(P<0.05).Multiple logistic regression identified that gender,duration of fever and dosage of IVIG were independent factors contributing to the development of coronary abnormalities. ConclusionBeing male,longer duration of fever,duration between onset and IVIG treatment and IVIG dosage,ESR and CRP are independent risk factors contributing to the development of coronary abnormalities.

Key words: Risk factor , Coronary complication