关键词: 糖尿病酮症酸中毒, 脑水肿, 儿童

Abstract: AbstractObjectiveTo explore the clinical characteristics of cerebral edema in children with diabetic ketoacidosis. MethodsThe clinical data of 71 children with diabetic ketoacidosis admitted to the hospital from 1993 to 2005 were analysed.The clinical characteristics and possible etiological factors between children with cerebral edema,and those with equal severe diabetic ketoacidosis but without cerebral edema were compared. ResultsSix cases in 71 children with diabetic ketoacidosis were identified in developed cerebral edema.The incidence of cerebral edema in the patients of this group was 84%.They all suffered severe ketoacidosis.Compared the children with equal severe diabetic ketoacidosis but without cerebral edema,6 children suffered more severe metabolic acidosis,experienced an attenuated rise in measured serum sodium concentrations or hyponatremia during therapy for diabetic ketoacidosis and had higher initial serum urea nitrogen concentrations.Five cases in 6 children with cerebral edema had been administrated bicarbonate treatment. ConclusionThe severe diabetic ketoacidosis is much more easy to develop cerebral edema.Children with diabetic ketoacidosis who have severe metabolic acidosis,a smaller increases in serum sodium concentration or hyponatremia during therapy and high serum urea nitrogen concentrations,and children who are treated with bicarbonate are at increased risk for developing cerebral edema.

Key words: Children , Cerebral edema