关键词: 毛细血管内增生性肾炎, 肾病综合征

Abstract: AbstractObjectiveTo analyze the clinical manifestation,pathological changes and treatment of 6 patients with nephrotic syndrome(NS) due to endocapillary proliferative glomerulonephritis(EPGN) MethodsThe data of patients with NS due to EPGN admitted to our department from 2002 to 2004 were retrospectively analyzed. Results(1)All the 6 patients were manifested clinically by nephritis nephrotic syndrome.(2)The pathological features showed that cell crescent was formed on the basis of endocapillary proliferation;the granular deposition of IgG and C3 was found along the blood capillary,and “nontypical hump” and partial foot process fusion were also detected.(3)Treatment:6 cases were treated with methyprednisolone.Two cases completely alleviated,4 cases weren’t.Among these 4 cases,2 cases were treated with cyclohosphamide,and 2 cases were treated with common three-wing-nut Root,all of them being cured. Conclusion(1)There is close relation ship between pathological changes and clinical manifestations.Those with crescent were presented with long duration of hematuria and those with foot process fusion have long duration of severe proteinuria.(2)Enough doses of steroid should be given once diagnosis is confirmed.A satisfactory effect could be achieved through combination with immunosuppressant if there is no responses after 4 weeks of steroid.But long term prognosis is yet to be investigated.

Key words: Nephrotic syndrome