关键词: 儿童, IgA肾病, 临床表现, 病理学

Abstract: AbstractObjectiveTo investigate clinical and pathological features of children with IgA nephropathy (IgAN). MethodsTo characterize the clinical manifestations and pathological changes of 64 children with IgAN depending upon the course of disease and clinical type. ResultsIsolate hematuria and nephrotic syndrome of IgAN were major clinical types in 64 cases,accounting for 73% (47/64).Upon the course of disease,three pathological changes such as inflammation cells infiltration,renal tubule degeneration and renal interstitial fibrosis predominated,of whom renal interstitial fibrosis unbalancedly distributed between the group of less than or equal to one year and more than one year,which was closely related to unbalanced distribution of nephrotic syndrome IgAN,in which the three changes were more obvious than other clinical type of IgAN. ConclusionIn 64 children with IgAN,isolate hematuria and nephrotic syndrome are main clinical type of IgAN.Nephrotic syndrome IgAN or continuous proteinuria is the major cause leading to renal interstitial fibrosis.Early control of proteinuria would delay or decrease renal interstitial fibrosis.

Key words: Pathology , IgA nephropathy, Clinical presentation