中国实用儿科杂志

中国实用儿科杂志

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单纯性肥胖男性儿童瘦素与几种内分泌指标检测与分析

杜虹1，才绍江1，丁凤姝1，冯冰2，苏敏1，王岚1，张颖1   

  1. 1.哈尔滨市儿童医院内七病房，黑龙江哈尔滨 150010；2.中国人民解放军211医院儿科，黑龙江哈尔滨 150001
  • 收稿日期:2005-07-10 修回日期:2005-11-10 出版日期:2006-02-06 发布日期:2006-02-06

Detection and analysis of endocrinal markers and leptin in obesity boys.

Du Hong,Cai Shaojiang,Ding Fengshu,et al.   

  1. Harbin Children's Hospital,Harbin 150010,China
  • Received:2005-07-10 Revised:2005-11-10 Online:2006-02-06 Published:2006-02-06

摘要： 目的研究肥胖男性儿童的内分泌变化和瘦素(Leptin)对肥胖男性儿童的内分泌功能的作用。 方法肥胖组为2000~2004年在哈尔滨市儿童医院门诊就医体重高于同年龄小儿标准体重20%的患儿90例，对照组为体检正常的男性儿童共90名，年龄在5~16岁。测定身高体重指数(BMI)，Leptin、胰岛素、性腺系列、血脂系列，进行统计学分析。 结果肥胖男性儿童与正常男性儿童比较，Leptin、胰岛素、雌二醇、总胆固醇、甘油三脂、A/B、低密度脂蛋白、极低密度脂蛋白有显著的增加，睾酮、黄体生成素(LH)有显著的减少；肥胖男性儿童身高体重指数与Leptin、胰岛素、黄体酮、催乳素、载脂蛋白A、A/B之间有显著的负相关，与雌二醇、载脂蛋白B、极低密度脂蛋白之间有显著的正相关。 结论Leptin可作为评价肥胖男性儿童内分泌功能的一项指标，Leptin与胰岛素、皮质醇、性激素等可能存在相互作用，对机体发育、能量代谢、应激反应等方面有所影响。

关键词: 肥胖男性儿童, 瘦素, 内分泌功能

Abstract: AbstractObjectiveTo study the changes of the endocrinal function and the relations between leptin and the endcrinal function in obesity boys. MethodsObesity group and control group are made up of 90 cases each,who were treated in our OPD between 2000 and 2004,aged 5 to 16 years.We have measured the levels of BMI,leptin,insulin,corticoids,sex steroids,blood lipide and had made statistical analysis of all the data. ResultsCompared with normal boys,obesity boys have remarkably higher levels of leptin,insulin,corticoids,estrovite,total cholesteroid,triglyceride,A/B,low density lipoprotein,very low density lipoprotein and obviously lower levels of testosterone and lateining hormone.BMI of obesity boys was correlatd negatively with levels of lepin,insulin,progesterone,prolactin、apoproteinA、A/B and positively with levels of corticoids,estrovite,apoprotein B and very low density lipoprotein. ConclusionSerum leptin level may be of a marker to evaluate the endocrinal function in obesity boys and interacts with insulin,corticoids and sex steroids.So it has influence on development of body,energy metabolism and stress reaction.

Key words: Endocrinal function , Leptin