中国实用儿科杂志

中国实用儿科杂志

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孕妇产前进行免疫阻断与新生儿乙型肝炎基因疫苗免疫效果关系的研究

马宁生1，朱敏2，应红华2，林益平1   

  1. 1.金华职业技术学院医学院，浙江金华 321000；2.金华市人民医院
  • 收稿日期:2005-07-10 修回日期:2005-11-10 出版日期:2006-01-06 发布日期:2006-01-06

A study on correlation between immune interruption of antenatal birth in pregnant women and immune effect of hepatitis B gene vaccine in neonates.

Ma Ningsheng,Zu Ming,Ying Honghua,et al.   

  1. Jinhua College of Profession and Technology,Jinhua 321000,China
  • Received:2005-07-10 Revised:2005-11-10 Online:2006-01-06 Published:2006-01-06

摘要： 目的探讨采用乙型肝炎免疫球蛋白(HBIG)阻断孕妇乙型肝炎病毒(HBV)感染对新生儿乙型肝炎(简称乙肝)基因疫苗免疫效果的影响。方法对55例HBV标志物阳性孕妇于产前28周、32周和36周分别给予HBIG 200IU免疫阻断作为阻断组；31例HBV标志物阳性孕妇未给予HBIG免疫阻断作为未阻断组；同期选择HBV标志物阴性孕妇42例作为对照组。对三组新生儿分别给予乙肝基因疫苗的免疫接种，并分别于1个月、2个月、7个月和12个月龄采集外周血检测HBV标志物及丙氨酸转氨酶(ALT)。结果阻断组、未阻断组和对照组新生儿免疫保护率分别为87.3%(48/55)、77.4%(24/31)和97.6%(41/42)；未阻断组与对照组间比较具有统计学意义(P<0.01)；对“大三阳”孕妇的阻断效果最好，新生儿抗HBs阳转率从33.3%上升到71.4%。结论对HBV感染孕妇采用HBIG免疫阻断，可以降低宫内感染及母婴传播的发生率；分娩时孕妇HBV感染状态对新生儿抗HBs阳转率可能产生一定程度的影响。

关键词: 阻断, 乙型肝炎病毒, 宫内传播, 肝炎疫苗

Abstract: AbstractObjectiveTo explore the effect on neonatal immunization with hepatitis B gene vaccine by interrupting HBV infection in pregnant women with HBIG 200IU.Methods55 cases of HBV marks positive pregnant women given HBIG immunity 28、32 and 36 weeks before laboring were classified as interrupting group(group Ⅰ).31 cases without HBIG immunity as noninterrupting group(group Ⅱ).42 cases of healthy women were classified as control group in the corresponding period.Neonates in the three groups has been vaccinated respectively,and detected of HBV marks and ALT with blood samples in neonates of one,two and twelve months of age.ResultsThe immunization protective rates in group Ⅰ,Ⅱ and the control one were 87.3% (48/55),77.4%(24/31),and 97.6%(41/42).There were significant differences between group Ⅱ and the control group.(P<0.01).Best effect was seen in all three HBV marks positive pregnant women,and their neonatal antiHBS positive transformation increased from 33.3% to 71.4%.ConclusionHBV infected pregnant women with HBIG immunity can decrease the rate of intrauterine transmission and maternalinfantile transmission.Maternal HBV infection state might produce some effects on neonatal antiHBS positive transformation.

Key words: Hepatitis B vaccine , Hepatitis B virus, Intrauterine transmission