中国实用儿科杂志

中国实用儿科杂志

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影响生长板上软骨细胞活动的信号通路及生长板生物钟

  

  1. 国家儿童医学中心  首都医科大学附属北京儿童医院内分泌遗传代谢科， 北京  100045
  • 出版日期:2021-08-06 发布日期:2021-09-09

Signaling pathway and circadian clock of growth plate affecting chondrocyte activities of growth plate

  1. Department of Endocrinology，Genetics and Metabolism，Beijing Children’s Hospital，Capital Medical University，National Center for Children’s Health，Beijing  100045，China
  • Online:2021-08-06 Published:2021-09-09

摘要： 人的骨骼生长主要通过膜内骨化和软骨内骨化实现，其中位于生长板的软骨内骨化过程是最主要的增高机制。生长板是位于骨骺末端的由软骨细胞及其分泌的细胞外基质（ECM）构成的柱状结构。软骨细胞是生长板上唯一的细胞成分，故几乎所有的内分泌因子和转录调控因子等都是通过影响软骨细胞活动实现成骨的调控。该文重点介绍一些通过影响生长板上软骨细胞来调控成骨的信号通路以及生长板生物钟。

关键词: 生长板, 软骨细胞, 信号通路, 生物钟, 时钟基因

Abstract: The bone growth of human body is achieved mainly through two ways，intramembranous ossification and endochondral ossification，the endochondral ossification process on the growth plate is the main mechanism of growth. Growth plate is a columnar structure at the end of epiphysis，which consists of chondrocytes and extracellular matrix（ECM） secreted from chondrocytes. Chondrocyte is the unique cell type on the growth plate，therefore almost all of the endocrine factors and transcriptional regulation factors are functioning by regulating the activity of chondrocytes. So，this essay will introduce some signaling pathways that regulate ossification through affecting the chondrocytes of growth plate and circadian clock of the growth plate.

Key words: growth plate, chondrocyte, signaling pathway, circadian clock, clock gene