中国实用儿科杂志

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尿α1微球蛋白与微量白蛋白比值诊断Dent病临床价值研究

  

  1. 1.北京大学第一医院儿科,北京  100034;2.广东省佛山市妇幼保健院儿科,广东  佛山  528000
  • 出版日期:2017-05-06 发布日期:2017-05-10

Diagnostic value of the ratio of α1-microglobulinuria to microalbuminuria in Dent disease

  1. *Department of Pediatrics,Peking University First Hospital,Beijing  100034,China
  • Online:2017-05-06 Published:2017-05-10

摘要:

目的    探讨肾早期损伤指标中α1微球蛋白与微量白蛋白比值在Dent病诊断中的价值。方法 2014年1月至2015年12月北京大学第一医院儿科收治Dent病患儿8例,检测肾早期损伤指标、尿蛋白电泳,分析尿α1微球蛋白与微量白蛋白比值,及其与尿蛋白电泳低分子蛋白百分比的相关性。结果 8例Dent病肾早期损伤指标以α1微球蛋白升高最为显著,尿α1微球蛋白与微量白蛋白比值均>1,该比值与尿蛋白电泳低分子蛋白百分比呈正相关(P<0.05)。结论 尿α1微球蛋白与微量白蛋白比值>1可作为小分子蛋白尿的一个判断指标,用于临床Dent病等小分子蛋白尿相关疾病的诊断。

关键词: Dent病, &alpha, 1微球蛋白, 微量白蛋白, 诊断价值

Abstract:

Objective To explore the diagnostic value of the ratio of α1-microglobulinuria to microalbuminuria in Dent disease. Methods Data were collected from 8 patients with childhood Dent disease from Jan.1,2014 to Dec.31,2015. The ratio of α1-microglobulinuria to microalbuminuria,and urine protein electrophoresis were monitored and analyzed. Results In all the 8 cases,α1-microglobulinuria was increased significantly,the ratio of α1-microglobulinuria to microalbuminuria was much higher than 1,and was closely related to the percentage of low molecular weight proteinuria in urine protein electrophoresis (P<0.05). Conclusion The ratio of α1-microglobulinuria to microalbuminuria over 1 can be used as a diagnostic criteria for tubuloproteinuria.

Key words: Dent disease;&alpha, 1-microglobinuria;microalbuminuria;diagnostic value