Abstract：Objective To study character of the serum sex hormone binding globulin (SHBG) level and insulin resistance in patients with history of recurrent spontaneous abortion during early pregnancy, evaluate the outcome of pregnancy. Methods 122 patients with history of recurrent spontaneous abortion registered for treatment in the Shengjing Hospital of China Medical University between June 2011 and June 2013 were selected into case group. 56 healthy women during early pregnancy were selected into control group.In pregnancy 8-10 weeks,data and serum specimens of women were collected in the cases group and the control group. To detect the indexes of SHBG, fasting blood glucose (FPG),fasting insulin (FINS), estradiol (E2), testosterone (T), dehydroepiandrosterone sulfate (DHEAS). Serum SHBG determination by enzyme linked immunosorbent assay (ELISA) method. FPG determinate by oxidase method. FINS,E2,T,DHEAS detected by chemiluminescence immunoassay.Results （1）Maternal body height, diastolic blood pressure and detecting gestational weeks in comparison, their difference in case group and in control has no statistical significance（P>0.05).The age of pregnancy women in case group and in control group in comparison, their difference has statistical significance（P<0.05).The body weight, body mass index, systolic blood pressure, previous pregnancy and history of recurrent spontaneous abortion in case group and in control group in comparison, their difference has statistical significance (P<0.01). （2）The SHBG,FPG,FINS,HOMA-IR and DHEAS in case group and in control group in comparison, their difference has statistical significance (P<0.01).The E2 and T of pregnancy women in case group and in control group in comparison, their difference has no statistical significance（P>0.05). （3）Body height, body mass index,SHBG and DHEAS in analysis of multiplicity were the influencing factors on recurrent spontaneous abortion (P<0.01). Conclusion Insulin resistance in early pregnancy women with history of recurrent spontaneous abortion increased than normal pregnant women，and HOMA-IR decreased than normal pregnant women. SHBG were one of the influencing factors on recurrent spontaneous abortion.