中国实用儿科杂志

中国实用儿科杂志

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学龄前儿童血清25羟维生素D调查分析

缪美华，邵雪君，朱宏，张晓燕   

  1. 作者单位：苏州大学附属儿童医院检验科，江苏 苏州 215003
  • 出版日期:2014-07-06 发布日期:2014-06-26
  • 通讯作者: 邵雪君 
  • 基金资助:

    苏州科技发展项目[SYS201248]

The investigation of serum 25-hydroxyvitamin D in preschool children.

MIAO Mei-hua，SHAO Xue-jun，ZHU Hong，ZHANG Xiao-yan.   

  1. The Children Hospital Affiliated to Soochow University，Suzhou 215003，China
  • Online:2014-07-06 Published:2014-06-26

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摘要：

目的 调查5月份苏州地区部分学龄前儿童血清25羟维生素D［25（OH）D］水平，为儿童摄入及补充维生素D提供依据。方法 2012年5月选取苏州城区及郊区来苏州大学附属儿童医院体检的学龄前儿童852名为研究对象， 年龄3～7岁， 其中男454名、 女398名。分为3～4岁、 ＞4～5岁、 ＞5～6岁和＞6～7岁4组。测定身高和体重， 以体重指数（BMI）评价儿童体型分为超重与非超重组， 肥胖与非肥胖组。采用ELISA法测定所有研究对象血清25（OH）D水平。结果 3～4岁血清25（OH）D高于＞4～5岁、 ＞5～6岁、 ＞6～7岁3组， 差异有统计学意义（χ2依次为110.43、 216.54和198.18， P均＜0.05）； ＞4～5岁血清25（OH）D高于＞5～6岁、＞6～7岁两组， 差异有统计学意义（χ2分别为106.11和87.75， P均＜0.05）。361例（42.37%）存在血清25（OH）D缺乏， 344例（40.38%）存在血清25（OH）D不足。不同性别间血清25（OH）D差异无统计学意义（χ2 = 1.23， P＞0.05）。超重与非超重儿童血清 25（OH）D 分布分别为 53.97（45.27～66.45） nmol/L和52.64 （42.85～63.80） nmol/L； 而肥胖与非肥胖儿童分别为55.24（47.29～66.56） nmol/L和 52.71（43.11～63.92） nmol/L，组间血清25（OH）D分布差异均有统计学意义（χ2分别为7.10和6.73，P均＜0.05）。血清25 （OH）D与 BMI 呈正相关 （r = 0.11，P＜0.05）。结论 所调查苏州地区部分学龄前儿童血清 25（OH）D 总体不足。儿童血清25（OH）D与BMI呈正相关。应加强血清25（OH）D监测，并采取科学措施加强学龄前儿童维生素D摄入及补充。

关键词: 学龄前, 儿童, 25羟维生素D, 体重指数

Abstract:

Abstracts： Objective To study serum 25-hydroxyvitamin D ［25-hydroxyvitamin D，25（OH）D］ distribution in May in preschool children in Suzhou area， giving scientific basis for the intake and supplementation of vitamin D for children. Methods Totally 852 cases of preschool children（454 cases of male，398 cases of female） aged from 3 to 7 years were selected in May of 2012，and all cases were divided into four groups named as 3～4 year group，＞4～5 year group，＞5～6 year group and ＞6～7 year group.The height and weight of every case were measured and were used to calculate the Body Mass Index（BMI）for evaluating the body shape； according the normal reference values of P85 and P95 of BMI for children below 7 years old provided by WHO，all cases were classified into overweight or no-overweight，obesity or no obesity groups. Serum 25（OH）D levels were measured by ELISA. Results There were 42.37%（361/852）of cases for preschool children in Suzhou area who showed deficiency of serum 25（OH）D，and insufficiency was presented in 40.38%（344/852） of cases.For the distribution of 25（OH）D among age groups， they were 61.20（53.30～75.20）nmol/L，55.50（45.5～65.10）nmol/L，48.30（40.40～57.50）nmol/L and 48.90（40.40～60.20）nmol/L from 3～4 year group to ＞6～7 year group in turn. Comparing every two groups， the serum 25（OH）D declined with the increasing age except between ＞5～6 year and＞6～7 year group（χ2 =18.10，P=0.47），and it was higher in 3～4 year group than that in ＞4～5 year group（χ2 =110.43，P＜0.05），higher in ＞4～5 year group than that in ＞5～6 or ＞6～7 year group（χ2 was 106.11 and 87.75，P＜0.05 for all）.The distribution of serum 25（OH）D in overweight and no-overweight group was 53.97（45.27～66.45）nmol/L and 52.64（42.85～63.80）nmol/L， and they were 55.24（47.29～66.56）nmol/L and 52.71（43.11～63.92）nmol/L for obesity and no-obesity group，there existing significant difference for the distribution of 25（OH）D between every two groups（χ2 was 7.10 and 6.73，P＞0.05）. Serum 25（OH）D and BMI showed positive correlation（r = 0.11，P＜0.05）. Conclusion The overall insufficiency of serum 25（OH）D exists in preschool children in Suzhou area，and positive correlation exists between BMI and serum 25（OH）D in children. It suggests that we should reinforce the monitoring of serum 25（OH）D in preschool children，taking scientific measures to strengthen the intake and supplementation of vitamin D.

Key words: preschool, child, 25-hydroxyvitamin D, body mass index

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